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MetabolomicsThe accumulation of methylglyoxal and acrolein leads to arginine depletion causing hyperglycemia and renal abnormalities

There is growing evidence to support the idea that the accumulation of reactive carbonyl species plays a significant causal role in the pathogenesis of ageing, cardiovascular diseases, diabetes and its complications. Among reactive carbonyl species, methylglyoxal and acrolein, detoxified by glyox...

2026-06-17 | MTBLS14089 | MetaboLights
TranscriptomicsTranscription profiling of mouse MH-S cell line with methylglyoxal induces apoptosis and immune response
Mycobacteria-induced apoptosis of macrophages plays an important role in modulation of the host immune response involving TNF-alpha as major cytokine. The underlying mechanisms are still ill-defined. Here, we show for the first time that methylglyoxal (MG) and AGEs levels were elevated during mycoba...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3837 | biostudies-arrayexpress
ProteomicsIDA-SWATH proteomic analysis of rat hippocampus upon methylglyoxal treatment
Diabetes is one of the major risk factors for Alzheimer’s disease (AD) development. The role of elevated levels of glucose, methylglyoxal (MGO), and advanced glycation end products (AGEs) in diabetes in the pathogenesis of the AD is not well understood. In this pursuit, we studied the role of methyl...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-26 | PXD037673 | Pride
Methylglyoxal Rat Hippocampus 
TranscriptomicsChIP-chip by array of E. coli MG1655 to analyzed the genome-wide redistribution of RNA polymerase upon methylglyoxal stress
We have analyzed the genome-wide redistribution of RNA polymerase in E.coli upon methylglyoxal stress. Herefore, we have used ChIP-chip against the beta subunit of RNA polymerase and we have assessed changes in RNA polymerase distribution upon sub-lethal and lethal concentrations of methylglyoxal.
ORGANISM(S): Escherichia coli 
2011-12-15 | E-MTAB-100 | biostudies-arrayexpress
TranscriptomicsThe global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA)
Abstract of associated menuscript; Quinones and alpha,beta-unsaturated carbonyls are naturally occurring electrophiles that target cysteine residues via thiol-(S)-alkylation. We analyzed the global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA...
ORGANISM(S): Bacillus subtilis 
2010-05-15 | E-GEOD-13925 | biostudies-arrayexpress
ProteomicsProfiling of Methylglyoxal Blood Metabolism and Advanced Glycation End-Product Proteome using a Chemical Probe
Methylglyoxal (MG) is a toxic byproduct of the glycolytic pathway and is quantitatively the most important precursor to advanced glycation end-products (AGEs). Insight into which proteins and in particular their individual modification sites are central to understand the involvement of MG and AGE in...
ORGANISM(S): Homo sapiens (Human) 
2019-07-31 | PXD011314 | Pride
Human Erythrocytes Plasma Methylglyoxal 
ProteomicsQuantitative chemoproteomic profiling of protein crosslinks induced by methylglyoxal
Quantitative chemoproteomic profiling of protein crosslinks induced by methylglyoxal
ORGANISM(S): Homo Sapiens Mus Musculus 
2022-01-03 | PXD030688 |
TranscriptomicsPhenotype Enhancement Screen of a Regulatory spx Mutant Unveils a Role for the ytpQ Gene in the Control of Iron Homeostasis.
Spx is a global regulator of genes that are induced by disulfide stress in Bacillus subtilis. Most of the Spx-regulated genes (SRGs) are of unknown function, but many encode products conserved in low %GC Gram positive bacteria. Using a gene-disruption library of B. subtilis genomic mutations, the SR...
ORGANISM(S): Bacillus subtilis 
2011-10-24 | E-GEOD-28872 | biostudies-arrayexpress
ProteomicsIdentification of methylglyoxal reactive proteins with photocaged glycating agents
Abstract Methylglyoxal is a highly reactive metabolite that is formed spontaneously in the glycolytic pathway. The side chains of various amino acid residues react with methylglyoxal to form advanced-glycation end products (AGEs). This enzyme-independent process introduces post-translational modific...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD061990 | Pride
Proteomics E coli A549 cell line Photocleavable reagent Advanced-glycation end products 
TranscriptomicsMicroarray expression of kidney cortex in adult male rats treated with methylglyoxal vs. controls
In our study, we investigated the effect of methylglyoxal on metabolic, transcriptomic, metabolomic and proteomic profiles in the context of the development of kidney impairment in an experimental model of metabolic syndrome. Dicarbonyl stress was induced in experimental group by intragastrical adm...
ORGANISM(S): Rattus norvegicus 
2020-02-08 | E-MTAB-7690 | biostudies-arrayexpress
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