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TranscriptomicsStrand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis
Although genome-wide transcriptional analysis has been used for many years to study bacterial gene expression, many aspects of the bacterial transcriptome remain undefined. A prominent example is antisense transcription, which has been observed in a number of bacteria, though the function of antise...
ORGANISM(S): Bacillus anthracis 
2012-03-15 | E-GEOD-36506 | biostudies-arrayexpress
TranscriptomicsRho and NusG suppress pervasive antisense transcription in Escherichia coli [RNA-seq].
Despite the prevalence of antisense transcripts in bacterial transcriptomes, little is known about how their synthesis is controlled. We report that a major function of the Escherichia coli termination factor Rho and its co-factor NusG is suppression of ubiquitous antisense transcription genome-wide...
ORGANISM(S): Escherichia coli K-12 
2012-11-01 | E-GEOD-41939 | biostudies-arrayexpress
TranscriptomicsEffects of AβPP Antisense Treatment on Hippocampal Gene Expression in Adult Mice with Memory Deficits
The purpose of this study was to determine the effect of peripheral (IV) administration of AβPP antisense on hippocampal gene expression as well as on learning and memory as measured by T-maze in adult male mice aged 12 months. The AβPP antisense treatment reversed learning and memory deficits and ...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-65877 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of expression and DNA methylation at CpG-island-associated sense-antisense transcript loci in mouse
Sense-antisense transcript (SAT) pairs are pairs of transcripts that fully or partially overlap but are transcribed in opposite directions. Although SAT expression occurs in various species, most SAT pairs have not been examined in detail. Because our previous studies revealed some tissue specificit...
ORGANISM(S): Mus musculus 
2010-08-26 | E-GEOD-14392 | biostudies-arrayexpress
TranscriptomicsThe effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus
Naturally occurring Antisense Transcripts (NATs) compose an emerging group of regulatory RNAs. These regulatory elements appear in all organisms examined, but little is known about global expression of NATs in fungi. Analysis of currently available EST sequences suggests that 352 cis NATs are pres...
ORGANISM(S): Aspergillus flavus 
2010-06-21 | E-GEOD-12594 | biostudies-arrayexpress
TranscriptomicsAntisense Expression of Annotated Genes
Contains a row for each annotated gene in each sample, indicating whether our analysis called the region antisense to the coding region of the gene "present" or "absent" in the sample. Gene names and coordinates refer to version 3 of the TIGR annotation as submitted to GenBank (GI numbers 22330780, ...
ORGANISM(S): Arabidopsis thaliana 
2010-06-05 | E-GEOD-637 | biostudies-arrayexpress
ProteomicsAntisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and 6 extracellular vesicles recycling
Next generation modified antisense oligonucleotides (ASOs) are commercially approved new therapeutic modalities, yet poor productive uptake and endosomal entrapment in tumour cells limit their broad application. We compared intracellular traffic of anti KRAS antisense oligonucleotide (AZD4785) in go...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD027804 | Pride
Antisense oligonucletides Lc-ms/ms 
ModelsLlorénsRico2016 - Effects of cis-Encoded antisense RNAs (asRNAs) - Case1
LlorénsRico2016 - Effects of cis-Encoded antisense RNAs (asRNAs) - Case1 Three putative effects of the asRNAs were considered in this study: in case 1  (this model) , the binding of the asRNA to the corresponding mRNA induces degradation of the duplex. In case 2, the binding of the ...
2017-05-18 | MODEL1511170000 | BioModels
ModelsLlorénsRico2016 - Effects of cis-Encoded antisense RNAs (asRNAs) - Case2
LlorénsRico2016 - Effects of cis-Encoded antisense RNAs (asRNAs) - Case1 Three putative effects of the asRNAs were considered in this study: in case 1 , the binding of the asRNA to the corresponding mRNA induces degradation of the duplex. In case 2   (this model)   the binding o...
2017-05-18 | MODEL1511170001 | BioModels
ModelsLlorénsRico2016 - Effects of cis-Encoded antisense RNAs (asRNAs) - Case3
LlorénsRico2016 - Effects of cis-Encoded antisense RNAs (asRNAs) - Case3 Three putative effects of the asRNAs were considered in this study: in case 1, the binding of the asRNA to the corresponding mRNA induces degradation of the duplex. In case 2, the binding of the asRNA to...
2017-05-18 | MODEL1511170002 | BioModels
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