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Next generation modified antisense oligonucleotides (ASOs) are commercially approved new therapeutic modalities, yet poor productive uptake and endosomal entrapment in tumour cells limit their broad application. We compared intracellular traffic of anti KRAS antisense oligonucleotide (AZD4785) in go...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD027804 | Pride
Antisense oligonucleotides (ASOs) are emerging as a promising therapeutic approach for many disorders. Currently, fourteen ASOs have been FDA/EMA-approved, with many more in preclinical development. An important requirement for preclinical studies is the inclusion of negative controls to properly as...
ORGANISM(S): Homo sapiens (Human) 
2026-09-01 | PXD070121 | Pride
Gene expression profile of modified gapmer antisense oligonucleotides treated mouse liver
Xenopus laevis embryos were injected with antisense oligonucleotides against TBP, TLF or TBP2. Embryos were allowed to develop up to stage 7 (non-injected control embryos) or stage 10.5 (early gastrula, control and antisense injected embryos) and subsequently collected for RNA and protein isolation...
ORGANISM(S): Xenopus laevis 
Targeting Smyd3 by antisense oligonucleotides attenuates liver tumor growth
We used our previously published isASO-ID protocol to identify binders for two different adenosine deaminases acting on RNA- (ADAR-) recruiting antisense oligonucleotides (ONs). The ONs differed in their phosphorothioate content and their RNA editing potency and efficiency through the recruitment of...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD066763 | Pride
Silencing of NFYC-AS1 by Gapmer antisense oligonucleotides and CRISPR/Cas9 TSS deletion.
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