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MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
TranscriptomicsIdentification of common human host genes involved in pathogenesis of different rota virus strains-an attempt to recognize probable antiviral targets
In this study, we aim to identify common human host genes involved in pathogenesis of different rota virus strains as an attempt to recognize probable antiviral targets. We have compared the host gene regulation after infection of human intestinal cell line (HT29) with three different wild type RV s...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-MEXP-3670 | biostudies-arrayexpress
ProteomicsA SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Purposing
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 170,000 people since the end of 2019, killed over 7,400, and caused worldwide social and economic disruption. SARS-CoV-2 infection has a mortality rate of 3.4% among confirmed case...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-03-24 | MSV000085144 | MassIVE
ProteomicsSubstrate trapping approach identifies TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes
The tripartite motif (TRIM) family of E3 ubiquitin ligases is well known for its roles in antiviral restriction and innate immunity regulation, in addition to many other cellular pathways. In particular, TRIM25-mediated ubiquitination affects both carcinogenesis and antiviral response. While individ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-02 | PXD034024 | Pride
Ubiquitination Trim25 Lcms 
UnknownAntiviral lectins: Selective inhibitors of viral entry.
Not available
S-EPMC5414728 | biostudies-literature
TranscriptomicsTranscription profiling of wild type mouse embryonic fibroblasts treated with interferon to study interferon-regulated gene expression.
A number of IFN-induced proteins are believed to be responsible for the antiviral state induced by IFNs. Our microarray analysis of IFN-regulated genes in MEFs from wild-type mice identified 124 probe sets that were differentially regulated upon IFN treatment. This group consisted of many known ISGs...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-3400 | biostudies-arrayexpress
UnknownOrthopoxvirus targets for the development of new antiviral agents.
Not available
S-EPMC3773844 | biostudies-literature
ProteomicsPhosphoproteomic Landscape of Pseudorabies Virus Infection Reveals Multiple Potential Antiviral Targets
A quantitative phosphoproteome was conducted to explore the phosphorylation changes and host cellular responses upon PRV infection. Besides, the characteristics of the phosphorylated proteins were analyzed, including molecular distribution, percentage of the phosphorylated (STY) sites, and phosphory...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-11-17 | PXD044682 | Pride
Phosphoproteomic landscape Pseudorabies virus Antiviral targets Virus-host interaction 
UnknownOrthopoxvirus targets for the development of antiviral therapies.
Not available
S-EPMC4264105 | biostudies-literature
GenomicsA reversible broad-spectrum antiviral targets the human V-ATPase VO domain
A reversible broad-spectrum antiviral targets the human V-ATPase VO domain
PRJNA1381702 | ENA
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