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MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
GenomicsPseudomonas sp. AP-1 isolate:wastewater treatment plants
Pseudomonas sp. AP-1 isolate:wastewater treatment plants Genome sequencing
PRJNA1131909 | ENA
TranscriptomicsInterplay between AP-1 and ERalpha in regulating gene expression and proliferation networks in breast cancer cells
Estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERalpha can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interaction...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36586 | biostudies-arrayexpress
GenomicsPseudoalteromonas sp. RW-H-Ap-1
Pseudoalteromonas sp. RW-H-Ap-1 Genome sequencing
PRJNA1144639 | ENA
GenomicsPseudoalteromonas sp. RW-H-Ap-1
Pseudoalteromonas sp. RW-H-Ap-1 Genome sequencing
PRJNA1192006 | ENA
TranscriptomicsTranscription profiling of human age-dichotomized ER+, N0 breast tumors reveals enhanced NF kappa B and AP-1 activity associated with antiestrogen resistant breast caner
Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic si...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7378 | biostudies-arrayexpress
GenomicsVibrio alginolyticus strain:AP-1
Vibrio alginolyticus strain:AP-1 Genome sequencing and assembly
PRJNA702834 | ENA
ProteomicsThe role of the AP-1 adaptor complex in outgoing and incoming membrane trafficThe role of the AP-1 adaptor complex in outgoing and incoming membrane traffic
The AP-1 adaptor complex is found in all eukaryotes, but it has been implicated in different pathways in different organisms. To look directly at AP-1 function, we generated stably transduced HeLa cells co-expressing tagged AP-1 and various tagged membrane proteins. Live cell imaging showed that AP-...
ORGANISM(S): Homo sapiens (Human) 
2024-04-03 | PXD050449 | Pride
Ap-1 Silac Ip-ms Trafficking 
TranscriptomicsThe AP-1 Transcription Factor c-Jun Prevents Stress-Imposed Maladaptive Remodeling of the Heart
Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and ma...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-47898 | biostudies-arrayexpress
TranscriptomicsFOXK2 promotes AP-1 mediated transcriptional regulation - transcription profiling FOXK2 induction
Transcription profiling of FOXK2 expression in HeLa cells from a stably integrated doxycyline-inducible EGFP-FOXK2 expression construct.
ORGANISM(S): Homo sapiens 
2011-11-03 | E-MEXP-3040 | biostudies-arrayexpress
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