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ProteomicsA protein adaptor mediating Ap4A-dependent control of protein acetylation.
Reversible lysine acetylation is a highly conserved post-translational modification across all domains of life, modulating diverse cellular processes. However, the regulatory mechanisms governing this modification remain poorly understood. Here, we uncover a novel regulatory system in Bacillus subti...
ORGANISM(S): Geobacillus thermodenitrificans NG80-2 
2026-01-21 | PXD064203 | Pride
Lysine acetylation Cbs Hdx-ms Ap4a 
UnknownThe mysterious diadenosine tetraphosphate (AP4A).
Not available
S-EPMC10148737 | biostudies-literature
UnknownSARS coronavirus protein 7a interacts with human Ap4A-hydrolase.
Not available
S-EPMC2831879 | biostudies-literature
UnknownChlamydia trachomatis CT771 (nudH) is an asymmetric Ap4A hydrolase.
Not available
S-EPMC3956076 | biostudies-literature
UnknownAlarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity.
Not available
S-EPMC6511005 | biostudies-literature
UnknownNUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.
Not available
S-EPMC4856261 | biostudies-literature
UnknownCrystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis.
Not available
S-EPMC2781443 | biostudies-literature
UnknownDiadenosine polyphosphates (Ap3A and Ap4A) behave as alarmones triggering the synthesis of enzymes of the phenylpropanoid pathway in Arabidopsis thaliana.
Not available
S-EPMC3642049 | biostudies-literature
TranscriptomicsTranscriptional profiling of a Staphylococcus aureus ΔyqeK mutant under acetic acid stress
Staphylococcus aureus YqeK is an Ap4A hydrolase that degrades the alarmone adenosine tetraphosphate (Ap4A). Ap4A is produced by aminoacyl-tRNA synthetases as a byproduct of aminoacylation during stress. In other bacteria, excessive Ap4A accumulation has been linked to reduced oxidative and heat stre...
ORGANISM(S): Staphylococcus aureus 
2026-05-15 | GSE319508 | GEO
TranscriptomicsTranscriptional profiling of a Staphylococcus aureus ΔyqeK mutant under nitric oxide stress
Staphylococcus aureus YqeK is an Ap4A hydrolase that degrades the alarmone adenosine tetraphosphate (Ap4A). Ap4A is produced by aminoacyl-tRNA synthetases as a byproduct of aminoacylation during stress. In other bacteria, excessive Ap4A accumulation has been linked to reduced oxidative and heat stre...
ORGANISM(S): Staphylococcus aureus 
2026-05-15 | GSE319509 | GEO
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