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GenomicsExpression profile of transcripts associated with Apcin-induced growth inhibition and apoptosis in endometrial carcinoma
Expression profile of transcripts associated with Apcin-induced growth inhibition and apoptosis in endometrial carcinoma
PRJNA704935 | ENA
TranscriptomicsExpression profile of transcripts associated with Apcin-induced growth inhibition and apoptosis in endometrial carcinoma
Background: Endometrial carcinoma (EC) is a common gynecological malignancy with increasing incidence and death rate during the past years. In order to obtain better prognosis, it is necessary to develop novel therapy strategies for EC, especially for molecular targeted therapy. CDC20 is an Anaphase...
ORGANISM(S): Homo sapiens 
2024-06-30 | GSE167548 | GEO
UnknownDesign, Synthesis, and Biological Evaluation of Apcin-Based CDC20 Inhibitors.
Not available
S-EPMC8842116 | biostudies-literature
UnknownDiscovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer.
Not available
S-EPMC9964651 | biostudies-literature
UnknownTargeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer.
Not available
S-EPMC11591962 | biostudies-literature
ProteomicsParadoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20
The Anaphase Promoting Complex/Cyclosome (APC/C) is a mega-dalton ubiquitin ligase that initiates mitotic exit by targeting substrates for degradation. The APC/C is activated by Cdc20, which acts as a substrate receptor, and is inhibited by the mitotic checkpoint complex (MCC), which delays mitoti...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD013786 | Pride
Cdc20 Mitosis Apcin 
TranscriptomicsDynamic tumor growth patterns in a novel murine model of colorectal cancer
Colorectal cancer often arises from adenomatous polyps. Polyps can grow and progress to cancer, but may also remain static in size, regress, or resolve. Prediciting which progress to cancer and which remain benign is difficult. We developed a long-lived murine model of colorectal cancer with tumo...
ORGANISM(S): Mus musculus 
2014-05-03 | E-GEOD-46626 | biostudies-arrayexpress
UnknownParadoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20.
Not available
S-EPMC7289404 | biostudies-literature
UnknownSynergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Not available
S-EPMC4214887 | biostudies-literature
UnknownDefective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
Not available
S-EPMC4600715 | biostudies-literature
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