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ProteomicsFunctional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling
Accurate chromosome segregation is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), to inhibit the anaphase-promoting complex or cyclosome (APC/C). Cdc20 is an essential mitotic regulator since it promotes mitotic exit through activating...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD045411 | Pride
Cdc20 cry box crispr cas9 mitosis 
ProteomicsCoupling of Cdc20 inhibition and activation by BubR1
Tight regulation of the APC/C-Cdc20 ubiquitin ligase that targets Cyclin B1 for degradation is important for mitotic fidelity. The spindle assembly checkpoint (SAC) inhibits Cdc20 through the mitotic checkpoint complex (MCC). In addition, phosphorylation of Cdc20 by Cyclin B1-Cdk1 independently inhi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-18 | MSV000086910 | MassIVE
GenomicsBulk RNA sequencing from sorted thymic populations and tumors from control Cdc20(+/D) and aneuploid Cdc20(D/AAA)mice
Bulk RNA sequencing from sorted thymic populations and tumors from control Cdc20(+/D) and aneuploid Cdc20(D/AAA)mice
PRJNA727854 | ENA
ProteomicsJuxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly (IGX-MS data)
During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC) to inhibit the anaphase-promoting complex/cyclosome (APC/C). The Mad1-Mad2 complex provides a catalytic platform for MCC assembly. Mad1-...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031872 | Pride
Cell cycle  spindle assembly checkpoint  mad1  bub1  cdc20  mitotic checkpoint complex 
GenomicsTranscriptome profiling of SK-N-SH neuroblastoma cells following CDC20 knockdown
Transcriptome profiling of SK-N-SH neuroblastoma cells following CDC20 knockdown
PRJNA1418744 | ENA
GenomicsPRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B
PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B
PRJNA917037 | ENA
ProteomicsParadoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20
The Anaphase Promoting Complex/Cyclosome (APC/C) is a mega-dalton ubiquitin ligase that initiates mitotic exit by targeting substrates for degradation. The APC/C is activated by Cdc20, which acts as a substrate receptor, and is inhibited by the mitotic checkpoint complex (MCC), which delays mitoti...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD013786 | Pride
Cdc20 Mitosis Apcin 
GenomicsEffect of indel in promoter of CDC20 on gene expression in A375 human melanoma cell line.
Effect of indel in promoter of CDC20 on gene expression in A375 human melanoma cell line.
PRJNA851716 | ENA
TranscriptomicsTranscriptome profiling of SK-N-SH neuroblastoma cells following CDC20 knockdown
To investigate the effect of CDC20 on gene expression of SK-N-SH neuroblastoma cells, we used CDC20-targeting shRNA to stably reduce the expression of CDC20 via lentiviral transduction, which was then subjected to RNA-seq.
ORGANISM(S): Homo sapiens 
2026-09-01 | GSE318447 | GEO
TranscriptomicsTranscriptome profiling of HepG2 cells in Cdc20 overexpressed and downregulated condition
Cdc20 acts as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. Here we tried to explore the novel transcription regulatory function of Cdc20 by means of altering Cdc20 level in HepG2 cells. We transiently over expressed Flag tagged Cdc20 (F) and siRNA m...
ORGANISM(S): Homo sapiens 
2021-12-06 | GSE99756 | GEO
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