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ProteomicsDifferential protein expression in the alveolar bone tissue of rats with apical periodontitis
The iTRAQ method was used to analyze differences in protein expression in alveolar bone tissue during the progression of apical periodontitis in rats.
ORGANISM(S): Rattus Norvegicus 
2025-01-16 | PXD059854 |
TranscriptomicsTranscript profiling of the pea shoot apical meristem highlights processes underlying its function and maintenance
Plant growth is the result of cell proliferation in the meristems, which requires a dynamic balance between the formation of new tissue and the maintenance of a set of undifferentiated stem cells. There is much that remains unknown about this vital developmental process. In this study, we have repor...
ORGANISM(S): Pisum sativum 
2010-05-19 | E-GEOD-9278 | biostudies-arrayexpress
TranscriptomicsSmoking-induced Disarray of the Apical Junctional Complex Gene Expression Architecture in the Human Airway Epithelium
The apical junctional complex (AJC), composed of tight junctions and adherens junctions, is essential for maintaining epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking-induced disease, are both associated with increased lung epit...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-20257 | biostudies-arrayexpress
GenomicsIn vivo CRISPR screens of Toxoplasma gondii targeting proteins of the apical complex and the pellicle.
In vivo CRISPR screens of Toxoplasma gondii targeting proteins of the apical complex and the pellicle.
PRJNA1226160 | ENA
TranscriptomicsArabidopsis AGO1 and AGO10 bound sRNAs
The shoot apical meristem (SAM) comprises a group of undifferentiated cells that divide to maintain the plant meristem and also give rise to all shoot organs. SAM fate is specified by class III HOMEODOMAIN-LEUCINE ZIPPER (HD-ZIP III) transcription factors, which are targets of miR166/165. In Arabido...
ORGANISM(S): Arabidopsis thaliana 
2012-08-03 | E-GEOD-39885 | biostudies-arrayexpress
TranscriptomicsRNAseq of dark dissected, 3 day old Arabidopsis (col0) seedlings, including cotyledons, apical hooks and hypocotyls
Seedling establishment is a critical developmental transition that contributes to survival in the local environment. While light is the primary cue driving de-etiolation, how abiotic stress shapes early development in darkness remains unclear. We show that salinity induces a photomorphogenic-like re...
ORGANISM(S): Arabidopsis thaliana 
2026-06-23 | E-MTAB-16552 | biostudies-arrayexpress
TranscriptomicsControl of neural specification programmes by the NuRD complex
Apical progenitors from wild type and NestinCre:Mbd3Flox/Flox embryos at E12.5, E14.5 and E16.5 were used for gene expression microarray analyses to identify gene expression changes dependent upon a functional NuRD complex.
ORGANISM(S): Mus musculus 
2015-12-12 | E-MTAB-1332 | biostudies-arrayexpress
ProteomicsBulk delivery of a preassembled apical surface initiates epithelial lumen formation
The creation of a microvilli-rich apical luminal domain is essential for epithelial tissue morphogenesis and is closely coordinated with the formation of the apical junctional complex (AJC). De novo lumenogenesis, in which epithelial cells establish apical identity by directing apical cargo to an ap...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2026-06-08 | PXD061234 | Pride
Epithelial polarity 
ProteomicsApical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma
Toxoplasma gondii is an intracellular parasite that causes the disease toxoplasmosis in humans. It is a member of the phylum Apicomplexa that also includes significant human pathogens such as Plasmodium spp. and Cryptosporidium spp. causing malaria and diarrheal disease, respectively. These parasite...
ORGANISM(S): Toxoplasma gondii 
2024-01-25 | PXD044588 | Pride
Toxoplasma Exocytosis Secretion Lmbd Snare Apical annuli Dense granules 
TranscriptomicsApical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state
Through their biased localization and function within the cell, polarity complex proteins are necessary to establish the cellular asymmetry required for tissue organization. Well-characterized germinal zones, mitogenic signals, and cell types make the cerebellum an excellent model for addressing the...
ORGANISM(S): Mus musculus 
2016-06-30 | E-GEOD-75696 | biostudies-arrayexpress
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