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MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
ProteomicsSyntaxin5’s flexibility in SNARE pairing supports Golgi functions
The intracellular transport system is an evolutionally conserved, essential, and highly regulated network of organelles and small transport carriers that traffic protein and lipid cargoes within the cell. The Conserved Oligomeric Golgi (COG) complex is the major Golgi Multisubunit Tethering Complex....
ORGANISM(S): Homo sapiens (Human) 
2023-06-26 | PXD036741 | Pride
Membrane trafficking Golgi Bet1l Vti1b Snap29 Gor1 Gosr2 Cog Snares Stx5 Ykt6 
ProteomicsDeficiency in the SNARE protein SYNTAXIN-11 causes a secondary B cell defect
CD4 T cell help requires functional SNARE protein SYNTAXIN-11 for successful interaction with B cells, CD40L mobilization and secretion of IL-2 and IL-10 to promote B cell differentiation, germinal centre formation and class switch. STX11-deficieny results in hypogammaglobulinemia suggesting a highe...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-03-01 | MSV000094210 | MassIVE
ProteomicsAP-MS analysis of Arabidopsis SNARE SYP132
SNARE SYP132 co-immunoprecipitant complexes were isolated from purified plasma membrane fractions and analysed by mass spectrometry.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-03-18 | PXD048655 | Pride
Arabidopsis thaliana Mass spectrometry Snare Membrane traffic 
UnknownSNARE Modulators and SNARE Mimetic Peptides.
Not available
S-EPMC9776023 | biostudies-literature
ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-23 | MSV000084122 | MassIVE
TranscriptomicsTranscription profiling of mouse macrophage response to LPS
RAW264.7 murine macrophages treated with LPS
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1459 | biostudies-arrayexpress
ProteomicsMass Spectrometry Uncovers Protein Interactions and Stoichiometry of Intermediates and Sub-complexes for SNARE Complex Assembly
The neuronal SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters into the synaptic cleft. While the gene...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-25 | PXD030619 | Pride
Native mass spectrometry Chemical cross-linking Snare complex Complexin-1 Signal transmission in neurons 
UnknownSupramolecular SNARE assembly precedes hemifusion in SNARE-mediated membrane fusion.
Not available
S-EPMC2575085 | biostudies-literature
ProteomicsMiniTurbo-based interactomics of two plasma membrane-localized SNARE proteins in Marchantia polymorpha
• Marchantia polymorpha is a model liverwort and its overall low genetic redundancy is advantageous for dissecting complex pathways. Proximity-dependent in vivo biotin-labelling methods have emerged as powerful interactomics tools in recent years. However, interactomics studies applying proximity la...
ORGANISM(S): Marchantia polymorpha 
2022-04-01 | PXD030429 | Pride
Snare protein Interactomics Membrane-trafficking Miniturbo Proximity labelling Marchantia polymorpha 
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