Apobec3 - OmicsDI

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Benjamin A. Garcia, Ph.D., FRSC John McCrea Dickson M.D. Presidential Professor Director of Quantitative Proteomics Penn Epigenetics Institute Department of Biochemistry and Biophysics Smilow Center for Translational Research Perelman School of Medicine University of Pennsylvania Room 9-124 (office) 3400 Civic Center Blvd Philadelphia, PA 19104 215-573-9423 (office) (1)
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Protein interaction map of APOBEC3 enzyme family

Human APOBEC3 enzymes are a family of single-stranded (ss)DNA and RNA cytidine deaminases that act as part of the intrinsic immunity against viruses and retroelements. APOBEC3s deaminate cytosine to form uracil which can functionally inactivate or cause degradation of viral or retroelement genomes. ...

ORGANISM(S): Homo sapiens (Human)

2024-04-16 | PXD044275 | Pride

APOBEC3 promotes squamous differentiation and metastases via IL1A/AP-1 signaling

PRJNA993295 | ENA

Exomes of HEK-293T cells overexpressing a human APOBEC3 cDNA

Whole exome sequencing of human HEK-293T cells transiently overexpressing a human APOBEC3 cDNA

PRJEB21854 | ENA

APOBEC3 promotes squamous differentiation and metastases via IL1A/AP-1 signaling

In urothelial carcinoma, up to 70% of mutations are caused by mutagenic activity of the APOBEC3 deaminases. To dissect the role of APOBEC3 in the progression of UC, we generated a mouse model UPPA with conditional knock out of Pten and Trp53 in addition to mouse Apobec3 (mA3) overexpression and scRN...

ORGANISM(S): Homo sapiens Mus musculus

2025-11-05 | GSE237016 | GEO

CBFb Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression [ChIP-seq]

The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 (A3) family of restriction factors. Recently, the cellular transcription cofactor CBFb was shown to form a complex with CRL5-Vif and to be essential for A3 degradation and vir...

ORGANISM(S): Homo sapiens

2013-01-17 | E-GEOD-42575 | biostudies-arrayexpress

DHX15 inhibits mouse APOBEC3 deamination.

Not available

S-EPMC11990775 | biostudies-literature

Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.

Not available

S-EPMC4036618 | biostudies-literature

APOBEC3-mediated restriction of RNA virus replication.

Not available

S-EPMC5899082 | biostudies-literature

Mechanisms of APOBEC3 mutagenesis in human cancer cells.