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GenomicsAPOBEC3B effect on Hepatocellular carcinoma
APOBEC3B effect on Hepatocellular carcinoma
PRJNA482435 | ENA
GenomicsMapping the genomic occupancy by flag-tagged APOBEC3B protein
Mapping the genomic occupancy by flag-tagged APOBEC3B protein
PRJNA795961 | ENA
ProteomicsThe RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B
Mutations in cancer are due in part to DNA cytosine deamination by APOBEC3B (A3B). While low in healthy tissues, A3B expression and activity are elevated in tumors and further increase in metastases. However, molecular mechanisms responsible for A3B transcriptional regulation are poorly understood. ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD020473 | Pride
Cancer Silac Dna pull-down Polyoma virus t antigen Apobec3b 
TranscriptomicsAPOBEC3B effect on Hepatocellular carcinoma
Analysis of Hepatocellular carcinoma (HCC) with overexpression of APOBEC3B. Results provide insight into the role of APOBEC3B in the regulation of tumor microenvironment.
ORGANISM(S): Mus musculus 
2026-01-12 | GSE117546 | GEO
GenomicsHuman APOBEC3B ORF cDNA transfectants of human HEK-293T cells
Overexpression of human APOBEC3B in human HEK-293T cells
PRJEB20622 | ENA
GenomicsR-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B
R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B
PRJNA625079 | ENA
OtherMapping the genomic occupancy by flag-tagged APOBEC3B protein
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3B) is a key molecular driver inducing mutations in multiple human cancers. APOBEC3B belongs to the APOBEC3 enzyme family, which consists seven closely related DNA deaminases that catalyse cytosine-to-uracil (C>U) editing of si...
ORGANISM(S): Homo sapiens 
2025-01-06 | GSE193227 | GEO
GenomicsR-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein implicated in cancer. However, its substrates in cells are not fully delineated. Here, APOBEC3B proteomics reveal interactions with a surprising number of R-loop factors. Biochemical experiments show APOBEC3B bindi...
ORGANISM(S): Homo sapiens 
2023-06-10 | GSE148581 | GEO
UnknownGATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.
Not available
S-EPMC7486697 | biostudies-literature
GenomicsAPOBEC3B facilitates a functional and necessary link between estrogen receptor mediated transcription and DNA repair
Oestrogen receptor-α (ER) is the principal transcription factor in the majority of breast cancers, driving expression of genes that control cell growth and endocrine response. Understanding the mechanisms of ER action is crucial for improving response to endocrine treatments. Recent studies show tha...
ORGANISM(S): Homo sapiens 
2015-09-07 | E-GEOD-57426 | biostudies-arrayexpress
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