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ProteomicsPlasma Extracellular Vesicles from PSEN1-E280A and APOE3 Christchurch patients
We isolated plasma EVs from MCI PSEN1E280A-APOE3 (n=10, mean age: 46, range 41-54), non-MCI PSEN1E280A-APOE3 (n=10, mean age: 34, range 22-48), and non-MCI PSEN1E280A-APOE3Ch (n=9, mean age: 35, range 16-51) participants, using differential centrifugation. EVs were characterized by nanoparticle trac...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD068363 | Pride
Mild cognitive impairment Extracellular vesicles Plasma Autosomal dominant alzheimer disease Apoe3 christchurch 
GenomicsAstrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice
Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice
PRJNA1425310 | ENA
UnknownProtective mechanisms against Alzheimer's disease in APOE3-Christchurch homozygous astrocytes.
Not available
S-EPMC12444642 | biostudies-literature
GenomicsDistinct tau neuropathology and cellular profiles of a APOE3 Christchurch homozygote protected against Autosomal Dominant Alzheimer’s dementia
Distinct tau neuropathology and cellular profiles of a APOE3 Christchurch homozygote protected against Autosomal Dominant Alzheimer’s dementia
PRJNA851960 | ENA
GenomicsIsogenic Human Stem Cell Models Reveal Mutation-Dependent Protective Mechanisms of APOE3 Christchurch
Isogenic Human Stem Cell Models Reveal Mutation-Dependent Protective Mechanisms of APOE3 Christchurch
PRJNA1495217 | ENA
UnknownResistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.
Not available
S-EPMC6898984 | biostudies-literature
UnknownAPOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer's cases.
Not available
S-EPMC10987717 | biostudies-literature
Unknown<i>APOE3</i> Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease.
Not available
S-EPMC12640232 | biostudies-literature
TranscriptomicsAstrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice
The rare APOE3-Christchurch (APOE3Ch) variant is linked to resistance against PSEN1 p.E280A-driven autosomal dominant Alzheimer’s disease (AD). Recent studies in AD mouse models have demonstrated an effect of APOE3Ch in reducing tau pathology and tau propagation, yet its effects on amyloid pathology...
ORGANISM(S): Mus musculus 
2026-04-08 | GSE319850 | GEO
UnknownDistinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.
Not available
S-EPMC9381462 | biostudies-literature
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