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ProteomicsApolipoprotein F in hyperlipidemia
Apolipoprotein F (ApoF) modulates lipoprotein metabolism by selectively inhibiting cholesteryl ester transfer protein (CETP) activity on LDL. This ApoF activity requires that it is bound to LDL. How hyperlipidemia alters total plasma ApoF and its binding to LDL are poorly understood. In this study, ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD029713 | Pride
Hypercholesterolemia Plasma lipid transfer proteins Hypertriglyceridemia Apolipoproteins Ldl metabolism Lipid biochemistry Apolipoprotein f Cholesteryl ester transfer protein Lipoproteins 
TranscriptomicsRegulation of Pattern Recognition Receptors by the Apolipoprotein A-I Mimetic Peptide 4F
The apolipoprotein A-I (apoA-I) mimetic peptide 4F displays prominent anti-inflammatory properties, including the ability to reduce vascular macrophage content. Macrophages are a heterogenous group of cells, represented by two principal phenotypes, the classically activated M1 macrophage and an alt...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-36933 | biostudies-arrayexpress
ProteomicsTargeted Proteomics Using Stable Isotope Labeled Protein Fragments Enables Precise and Robust Determination of Total Apolipoprotein(a) in Human Plasma
Lipoprotein(a), also known as Lp(a), is an LDL-like particle composed of apolipoprotein(a) (apo(a)) bound covalently to apolipoprotein B100. Plasma concentrations of Lp(a) are highly heritable and vary widely between individuals. Elevated plasma concentration of Lp(a) is considered as an independent...
ORGANISM(S): Homo Sapiens 
2023-02-17 | PXD026976 | panorama
TranscriptomicsInterleukin-7 promotes monocyte/macrophage arrest on endothelial cells
Background: It is recognized that atherosclerosis can regresses at least in animal models. However, little is known about the mechanisms. We induced regression of advanced atherosclerosis in apolipoprotein E deficient (APOE­/­) mice and studied underlying mechanisms. Unexpectedly, our study led to t...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-15914 | biostudies-arrayexpress
Proteomics,MultiomicsPlasma Proteome Profiling Reveals the Effects of Weight Loss on the Apolipoprotein Family and Systemic Inflammation Status
Sustained weight loss is the preferred intervention in a wide range of metabolic conditions, but the effects on an individual´s health state remain ill-defined and controversial. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone eight weeks of weight lo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-02 | MSV000080596 | MassIVE
ProteomicsLong-term liver expression of an apolipoprotein A-I mimetic peptide attenuates IFNα-induced inflammation and promotes antiviral activity
Apolipoprotein A-I mimetic peptides are amphipathic alpha-helix peptides that display similar functions to apolipoprotein A-I. Preclinical and clinical studies have demonstrated the safety and efficacy of apolipoprotein A-I mimetic peptides in multiple indications associated with inflammatory proces...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD023281 | Pride
Adeno-associated virus Antiviral Apolipoprotein a-i mimetic peptide Liver Type i ifn 
UnknownThe effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.
Not available
S-EPMC3282742 | biostudies-literature
UnknownF-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein.
Not available
S-EPMC1265841 | biostudies-literature
UnknownStructural differences between apolipoprotein E3 and E4 as measured by (19)F NMR.
Not available
S-EPMC2817840 | biostudies-literature
UnknownGenetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein F as a candidate.
Not available
S-EPMC153798 | biostudies-literature
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