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GenomicsTMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progression
This SuperSeries is composed of the following subset Series: GSE28948: TMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progression (gene expression data) GSE28950: TMPRSS2-ERG, HDACs and EZH2 are involved in ...
ORGANISM(S): Homo sapiens 
2012-04-26 | E-GEOD-28951 | biostudies-arrayexpress
ProteomicsRET Kinase Inhibition in Neuroendocrine Prostate Cancer, part 2
Increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost androgen receptor (AR) signaling. AVPC tumors may also...
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD012971 | Pride
Human Kinase Phosphoproteomics Prostate cancer Ret 
ProteomicsRET Kinase Inhibition in Neuroendocrine Prostate Cancer, part 1
Increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost androgen receptor (AR) signaling. AVPC tumors may also...
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD012970 | Pride
Ret Prostate cancer Kinase Phosphoproteomics 
GenomicsTMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progression (ChIP-Seq data)
Deregulation of the Androgen Receptor (AR) transcriptional network is a common hallmark in prostate cancers. To achieve its precise transcriptional role, AR needs to co-operate specifically with a plethora of cofactors. In prostate cancers, AR transcription collaborators are frequently aberrantly ov...
ORGANISM(S): Homo sapiens 
2012-04-26 | E-GEOD-28950 | biostudies-arrayexpress
TranscriptomicsAn Integrated Network of Androgen Receptor and TMPRSS2-ERG Gene Fusion in Prostate Cancer Progression (II)
Androgen receptor (AR) is a transcription factor that plays a central role in the growth and development of the normal prostate and its malignant transformation. More recently, a majority of prostate cancers have been shown to harbor recurrent gene fusions of the androgen-regulated gene, TMPRSS2, t...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-14092 | biostudies-arrayexpress
TranscriptomicsHIPK2 and MED19 are new regulators of androgen receptor in prostate cancer cells
The androgen receptor (AR) is a mediator of both androgen-dependent and castration- resistant prostate cancers. Identification of cellular factors affecting AR transcriptional activity could in principle yield new targets that reduce AR activity and combat prostate cancer, yet a comprehensive analy...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-43881 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of prostate tumors with or without androgen receptor splice variant
Background. Androgen receptor splice variant-7 (AR-V7) is a truncated form of the androgen receptor protein which lacks the ligand-binding domain, the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of AR-V7 in circ...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-56701 | biostudies-arrayexpress
TranscriptomicsResveratrol-induced gene expression profiles in human prostate cancer cells
This SuperSeries is composed of the following subset Series: GSE4299: Resveratrol-Induced Gene Expression Profiles in Human Prostate Cancer Cells GSE4300: Androgen arrays for Resveratrol-Induced Gene Expression Profiles in Human Prostate Cancer Abstract: OBJECTIVE: The transhydroxystilbene resverat...
ORGANISM(S): Homo sapiens 
2006-03-07 | E-GEOD-4399 | biostudies-arrayexpress
no omics definedTranscription profiling of human prostate cancer cells over-expressing androgen receptor following dihydrotestosterone treament
dose and time dependent responses of dihydrotestosterone in androgen receptor over-expressing prostate cancer cells.
ORGANISM(S): Homo sapiens 
2009-10-09 | E-MEXP-2286 | biostudies-arrayexpress
TranscriptomicsGene Expression analysis of castration-resistant prostate cancer bone metastases
Analysis of bone metastases tissue from castration-resistant prostate cancer patients at the RNA level in relation to expression of constitutively active androgen receptor variants termed AR-V7 and AR-V567es. Total RNA obtained from frozen bone metastases samples were analyzed using a gene expressio...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-29650 | biostudies-arrayexpress
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