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ProteomicsARAF interactome in mouse melanoma by LC-MS/MS
This project aims to investigate the role of ARAF in NRAS mutated melanoma by identifying new partners using LC-MS.
ORGANISM(S): Mus musculus (Mouse) 
2021-12-13 | PXD020155 | Pride
Araf Mouse Melanoma 
GenomicsMassive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is a fatal bile duct cancer with dismal prognosis and limited therapeutic options. By performing RNA- and exome sequencing analyses we have discovered a novel fusion event, FGFR2-PPHLN1 (16%), and damaging mutations in the ARAF oncogene (11%). Methods: mRNA and...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63420 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human lung andenocarcinoma cell line A549, in which ARAF was depleted and reconstituted with an empty vector control, ARAF wildtype, or a dimer deficient and kinase inactive mutant.
RNA sequencing analysis of A549 cells that were depleted for ARAF (shARAF) and reconstituted with either empty vector control (+EV) or ARAF wildtype (+ARAF) or dimer deficient ARAF kinase (+R362H) respectively to identify factors that are differentially regulated by ARAF and its kinase activity. In ...
ORGANISM(S): Homo sapiens 
2022-04-22 | GSE149626 | GEO
GenomicsTranscriptome analysis of human lung andenocarcinoma cell line A549, in which ARAF was depleted and reconstituted with an empty vector control, ARAF wildtype, or a dimer deficient and kinase inactive mutant.
Transcriptome analysis of human lung andenocarcinoma cell line A549, in which ARAF was depleted and reconstituted with an empty vector control, ARAF wildtype, or a dimer deficient and kinase inactive mutant.
PRJNA629473 | ENA
ProteomicsPhosphoproteomic analysis reveals the role of ARAF in regulating the apoptosis of porcine macrophages infected with Toxoplasma gondii
Toxoplasma gondii is an obligate intracellular protozoan of severe threat to humans and livestock. Macrophages are the cell type preferentially infected by T. gondii in vivo. Protein phosphorylation is an important post-translational modification involved in diverse cellular functions. ARAF is membe...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-04-27 | PXD044725 | Pride
Toxoplasma gondii  host cell  apoptosis  phosphorylation  araf  3d4/21 
UnknownOncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.
Not available
S-EPMC3973082 | biostudies-literature
TranscriptomicsDiverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans Cell (LCH) and non-Langerhans (non-LCH) histiocytoses, respectively. The discovery of BRAFV600E mutations in ~50% of these patients pr...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-GEOD-74442 | biostudies-arrayexpress
UnknownARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers.
Not available
S-EPMC8932670 | biostudies-literature
UnknownARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.
Not available
S-EPMC9271631 | biostudies-literature
UnknownCharacterization and inhibitor sensitivity of ARAF, BRAF, and CRAF kinases.
Not available
S-EPMC12630025 | biostudies-literature
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