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Transcriptomicsume6D_BY4741 on expression/splicing microarrays
ume6D_BY4741 vegetative RNA compared to WT_BY4741 vegetative RNA. ume6D haploid was generated in the BY4741 strain background (ATCC: 201388) by PCR-mediated cassette-based gene replacement where the UME6 ORF was replaced with KANMX6, the deletion was verified by PCR. Vegetatively grown; Dye swap; Re...
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-05 | E-GEOD-24680 | biostudies-arrayexpress
TranscriptomicsCompetition between pre-mRNAs for a limiting splicing machinery drives global changes in splicing
During meiosis in yeast, global splicing efficiency increases. The mechanism for this is relief of competition for the splicing machinery by repression of intron-containing ribosomal protein genes (RPGs). Repression of RPGs with rapamycin also increases splicing efficiency in vegetative cells. Reduc...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-22 | E-GEOD-44219 | biostudies-arrayexpress
TranscriptomicsPrp4-1 temperature shift
Prp4-1 and wt strains were grown at 26°C to A600 of 1.0, then an equal volume of 48°C media was added to bring the temperature to 37°C. Both strains were allowed to grow at 37°C and samples were taken at 0 (before shift), 5, 15, 30, 60, and 120 mins after shift to restrictive temperature. Keywo...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-27 | E-GEOD-34 | biostudies-arrayexpress
TranscriptomicsNon-essential mRNA processing factors
Set of experiments done on yeast deletion strains of various non-essential mRNA processing factors. Keywords = splicing
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-27 | E-GEOD-35 | biostudies-arrayexpress
UnknownMiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer.
Not available
S-EPMC4167263 | biostudies-literature
UnknownPhase I results on the efficacy, safety and pharmacokinetics of lurbinectedin and irinotecan in advanced solid tumors.
Not available
S-EPMC12515209 | biostudies-literature
TranscriptomicsMacrophages recognize the Helicobacter pylori type IV secretion system in the absence of TLR signaling
Helicobacter pylori conquered the world by colonizing the human stomach. There are two major groups of strains, one with and one without a cag pathogenicity island (cagPAI), which result in different clinical outcomes with increased severity in cagPAI+ H. pylori infections such as higher inflammatio...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-56791 | biostudies-arrayexpress
UnknownMAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma.
Not available
S-EPMC6098621 | biostudies-literature
TranscriptomicsGenome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing
SR proteins are well-characterized RNA binding proteins that promote exon inclusion by binding to exonic splicing enhancers (ESEs). However, it has been unclear whether regulatory rules deduced on model genes apply generally to activities of SR proteins in the cell. Here, we report global analyses o...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-44591 | biostudies-arrayexpress
TranscriptomicsExploring functional relationships between components of the gene expression machinery
Splicing and expression analysis of a collection of 80 different mutations to the gene expression pathway in yeast
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-1684 | biostudies-arrayexpress
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