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ProteomicsArg-C Ultra simplifies histone preparation for LC-MS/MS
Using mammalian histone extract, we demonstrate that Arg-C Ultra facilitates histone preparation for LC-MS/MS. We show the performance of Arg-C Ultra in terms of digestion specificity, number of modified forms identified, and yield of quantitative information compared with standard Arg-C and trypsin...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD059514 | Pride
Histone Arg-c ultra Trimethylacetic anhydride Lc-ms/ms Chemical derivatization 
ProteomicsReversible Lysine Derivatization Enables High Specificity of Arg-C Digestion Using Trypsin
Bottom-up proteomics approach has become an important strategy in diverse areas of biological research, and the enzymatic digestion is essential for this technology. Endopeptidase Arg-C catalyzing the hydrolytic cleavage of peptide bonds C-terminal to arginine could be an important protease in botto...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-01-04 | PXD007994 | Pride
Proteomics Arg-c Trypsin Lys-c Citraconylation Lc-ms/ms 
ProteomicsLys-C/Arg-C, a New Enzyme Combination for Next-Generation Proteomics
Today, the most widely used bottom-up proteomics studies necessitate a proteolysis step prior to MS analysis. Trypsin is often the best protease in choice due to its high specificity and MS-favored proteolytic products. Trypsin has been challenged for its low cleavage efficiency at Lys-X bonds, and ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-24 | PXD009797 | Pride
Lys-c / arg-c / trypsin / dia / mass spectrometry 
GenomicsArg C and Linezolid on Th17 cells
Arg C and Linezolid on Th17 cells
PRJNA668781 | ENA
GenomicsGene transcription in wild-type (WT) and c-abl/arg knockout MEFs
Gene transcription in wild-type (WT) and c-abl/arg knockout MEFs
PRJNA646708 | ENA
TranscriptomicsArg C and Linezolid on Th17 cells
Arg C and Linezolid were added to differentiating Th17 cells for 96h. Cells were harvested and sorted according to proliferation cycle before being lysed and having their RNA extracted.
ORGANISM(S): Mus musculus 
2020-10-15 | GSE159401 | GEO
TranscriptomicsGene transcription in wild-type (WT) and c-abl/arg knockout MEFs
Abl kinases, which are required for multiple cellular processes, including proliferation, apoptosis, adhesion, cell migration, and stress responses, widely participate in the regulation of gene transcription. To illustrate the role of Abl kinase in gene expression, the transcription of approximately...
ORGANISM(S): Mus musculus 
2021-01-14 | GSE154568 | GEO
UnknownSynergistic Arg-C Ultra and Lys-C Digestion for Quantitative Proteomics.
Not available
S-EPMC12338676 | biostudies-literature
UnknownActivation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C.
Not available
S-EPMC1347983 | biostudies-literature
UnknownArg-C Ultra Simplifies Histone Preparation for LC-MS/MS.
Not available
S-EPMC12199229 | biostudies-literature
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