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UnknownStructural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling.
Not available
S-EPMC10213020 | biostudies-literature
UnknownEffects of theophylline on ADCY5 activation-From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients.
Not available
S-EPMC9983822 | biostudies-literature
UnknownA conserved aspartate residue in [4Fe-4S]-containing HypD is required for [NiFe]-cofactor biosynthesis and for efficient interaction of the HypCD scaffold complex with HypE.
Not available
S-EPMC12130793 | biostudies-literature
ProteomicsMechanism of pharmacochaperoning in ATP-sensitive potassium channels revealed by cryo-EM
ATP-sensitive potassium (K-ATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic beta-cells to maintain glucose homeostasis. Mutations that impair channel folding or assembly prevent ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-12 | PXD014498 | Pride
Pharmacological chaperones  sulfonylureas  glinides  carbamazepine  sulfonylurea receptor 1  kir6.2  structure 
TranscriptomicsBru-seq nascent RNA sequencing of human and mouse cells: correlation to replication timing and genome instability
Bru-seq nascent RNA sequencing (PubMed ID 23973811) was performed on two primary human fibroblast cell lines, mouse embryonic stem cells, and GM12878 human lymphoblastoid cells. Read data, which include both exon and intron signals, were used to identify transcription unit spans genome-wide, where a...
ORGANISM(S): Homo sapiens 
2014-10-17 | E-GEOD-55862 | biostudies-arrayexpress
ProteomicsMS analysis of SARS-CoV2 proteins from patient samples
We developed a simple, MS-based method to specifically detect SARS-CoV-2 proteins from gargle solution samples of COVID-19 patients. Our protocol consists of an acetone precipitation and tryptic digestion of proteins contained within the gargle solution, followed by a targeted MS analysis. Our metho...
ORGANISM(S): Homo sapiens (Human) 
2020-06-26 | PXD019423 | Pride
Covid-19 Nucleoprotein Sars-cov-2 Mass spectrometry 
TranscriptomicsComparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing
Copy number variants (CNVs) are a major source of genetic variation in human health and disease. Previous studies have suggested replication stress, such as that caused by the polymerase inhibitor aphidicolin, as a causative factor in CNV formation, but existing data are technically limited in the ...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-26121 | biostudies-arrayexpress
TranscriptomicsNOD2 and desease associated variant NOD2-L1007fsinsC dependent genomewide transcriptional regulation in stable Flp-In HEK cells
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide (MDP) and variants of NOD2 are associated with chronic inflammatory diseases of barrier organs e.g. Crohn disease, asthma and atopic eczema. It is known that activation of NOD2 induces a variety of inflammatory...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-22611 | biostudies-arrayexpress
UnknownEffect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study.
Not available
S-EPMC12307040 | biostudies-literature
UnknownChanges in phenology mediate vertebrate population responses to temperature globally.
Not available
S-EPMC12800269 | biostudies-literature
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