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TranscriptomicspiRNA-mediated transgenerational inheritance of an acquired trait
The maintenance of genome integrity is an essential trait to the successful transmission of genetic information. In animal germ cells, piRNAs guide PIWI proteins to silence transposable elements (TEs) in order to maintain genome integrity. In insects, most of TE silencing in the germline is achieved...
ORGANISM(S): Drosophila melanogaster 
2012-04-13 | E-GEOD-34506 | biostudies-arrayexpress
TranscriptomicsMaternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells
Transposable elements (TEs), whose propagation can result in severe damage to the host genome, are silenced in the animal gonad by Piwi-interacting RNAs (piRNAs). piRNAs produced in the ovaries are deposited in the embryonic germline and initiate TE repression in the germline progeny. Whether the ma...
ORGANISM(S): Drosophila simulans 
2013-04-09 | E-GEOD-40592 | biostudies-arrayexpress
GenomicsThe role of SMCHD1 in the formation of constitutive heterochromatin
A large portion of the mammalian genome is assembled into constitutive heterochromatin which is highly compact and transcriptionally silent throughout the cell cycle. On the molecular level it is characterized by DNA methylation, “repressive” histone marks (hypoacethylation, H3K9 trimethylation, H4K...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-46462 | biostudies-arrayexpress
GenomicsNR2C/F orphan receptors induce telomere-genome rearrangements in ALT
Most sarcomas have complex karyotype and are characterized by multiple chromosomal rearrangements. Moreover, sarcomas very frequently maintain their telomeres by recombination in the process called Alternative Lengthening of Telomeres (ALT) which enables their continuous growth and immortalization. ...
ORGANISM(S): Homo sapiens 
2015-02-23 | E-GEOD-46237 | biostudies-arrayexpress
TranscriptomicsA user-friendly chromatographic method to purify small regulatory RNAs
The discovery of the small regulatory RNA populations has changed our vision of cellular regulations. Indeed, loaded on Argonaute proteins they formed ribonucleoprotein complexes that target complementary sequences and achieved widespread silencing mechanisms conserved in most eukaryotes. The recent...
ORGANISM(S): Drosophila melanogaster 
2013-06-13 | E-GEOD-40748 | biostudies-arrayexpress
TranscriptomicsMicroRNA-dependent transposable element transcriptional silencing in Drosophila somatic ovarian cells [RNA-Seq]
RNAi-related silencing mechanisms concern as diverse biological processes as gene regulation, mostly via the miRNA pathway, and defense against molecular parasites, mainly controlled by the siRNA and the piRNA pathways. In Drosophila somatic ovarian cells, transposable elements (TEs) are repressed b...
ORGANISM(S): Drosophila melanogaster 
2015-04-08 | E-GEOD-60972 | biostudies-arrayexpress
TranscriptomicsMicroRNA-dependent transposable element transcriptional silencing in Drosophila somatic ovarian cells [RIP-Seq]
RNAi-related silencing mechanisms concern as diverse biological processes as gene regulation, mostly via the miRNA pathway, and defense against molecular parasites, mainly controlled by the siRNA and the piRNA pathways. In Drosophila somatic ovarian cells, transposable elements (TEs) are repressed b...
ORGANISM(S): Drosophila melanogaster 
2015-04-08 | E-GEOD-60973 | biostudies-arrayexpress
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