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ProteomicsGenomes of trombidid mites reveal novel predicted allergens and laterally-transferred genes associated with secondary metabolism
Background Trombidid mites have a unique lifecycle in which only the larval stage is ectoparasitic. In the superfamily Trombiculoidea (“chiggers”), the larvae feed preferentially on vertebrates, including humans. Species in the genus Leptotrombidium are vectors of a potentially fatal bacterial infec...
ORGANISM(S): Leptotrombidium deliense Dinothrombium 
2018-09-18 | PXD008346 | Pride
Trombidid mites Genome Lc-msms Scrub typhus 
ProteomicsStage-specific proteomes from Onchocerca ochengi, sister species of the human river blindness parasite, uncovers adaptations to a nodular lifestyle
In spite of 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected. The aetiological agent, Onchocerca volvulus, is a filarial nematode with a complex lifecycle involving several distinct stages in ...
ORGANISM(S): Onchocerca ochengi (Filarial nematode worm) 
2016-05-31 | PXD002889 | Pride
Lc-msms River blindness Onchocerca ochengi 
ProteomicsProteomic analysis of the global response of an arthropod Wolbachia symbiont to doxycycline-induced stress
The bacterium Wolbachia (order Rickettsiales), representing perhaps the most abundant vertically transmitted microbe worldwide, infects arthropods and filarial nematodes. In arthropods, Wolbachia can induce reproductive alterations and interfere with the transmission of several arthropod-borne patho...
ORGANISM(S): Wolbachia sp. wMelPop 
2013-10-21 | PXD000345 | Pride
Tetracyclines/tolerance/wolbachia/lc-msms 
ProteomicsUnique insights in cervicovaginal Lactobacillus iners and L. crispatus proteome changes associated with microbiome dysbiosis
Cervicovaginal lavage (CVL)supernatants were heat inactivated for 30 minutes at 56°C before further processing. Total protein concentrations were determined using the Pierce Coomassie Plus (Bradford) Protein Assay (Thermo Scientific, Rockford, IL, USA). Sample protein content and volume were normali...
ORGANISM(S): Homo sapiens (Human) Lactobacillus iners Lactobacillus crispatus 
2016-03-15 | PXD003176 | Pride
Label free proteomics Cervicovaginal microbiome dysbiosis 
ProteomicsDissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms
Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes and a bovine gastrointestinal (GI) isolate. Key genomic differences between bovine and human treponemes implicate microbial mechanisms t...
ORGANISM(S): Treponema sp. T19 Treponema pedis Treponema ruminis Treponema phagedenis Treponema medium Treponema sp. T320A 
2021-03-16 | PXD022419 | Pride
Bovine digital dermatitis Treponemes Shotgun lc msms 
ProteomicsDraft genome of the honey bee ectoparasitic mite, Tropilaelaps mercedesae, is shaped by the parasitic life history
Background The number of managed honey bee colonies has considerably decreased in many developed countries in recent years and the ectoparasitic mites are considered as major threats to honey bee colonies and health. However, their general biology remains poorly understood. Results We sequenced the...
ORGANISM(S): Tropilaelaps mercedesae 
2017-01-02 | PXD004997 | Pride
Honey bee Tropilaelaps mercedesae Label-free proteomics 
ProteomicsCervicovaginal dysbiosis is associated with significant changes in the cervicovaginal proteome related to immune activation and increased cell death
Cervicovaginal microbiome dysbiosis is associated with increased prevalence and incidence of sexually transmitted infections including HIV. We compared the cervicovaginal proteome as characterised by mass-spectrometry of four groups of African female sex workers (total N=50) grouped by microbiome co...
ORGANISM(S): Homo sapiens (Human) 
2015-09-25 | PXD001435 | Pride
Bacterial vaginosis/ cervicovaginal microbiome/ cervicovaginal proteome/ hiv/ lactobacillus crispatus/ mass spectrometry 
ProteomicsViral pIC-pocketing: RSV sequestration of eIF4F Initiation Complexes into bi-phasic biomolecular condensates
Orthopneumoviruses characteristically form membrane-less cytoplasmic inclusion bodies (IBs) wherein RNA replication and transcription occur. Herein, we report a strategy whereby the orthopneumoviruses sequester various components of the eiF4F Initiation Complex machinery into viral IBs to facilitate...
ORGANISM(S): Homo sapiens (Human) 
2024-02-02 | PXD041843 | Pride
Respiratory syncytial virus Eif4f complex Inclusion bodies 
ProteomicsComparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites
Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of approximately 6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No vaccine exists for the major filaria...
ORGANISM(S): Litomosoides sigmodontis (Filarial nematode worm) 
2014-07-22 | PXD000756 | Pride
Filarial nematode Excretory-secretory products Lc-ms/ms Litomosoides sigmodontis 
ProteomicsDetermination of the interactome of Non-Structural Protein12 from Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus with Host Cellular Proteins UsingHigh Throughput Proteomics and Identification of Hsp70 as a Critical Cellular Factor for Virus Biology
Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide. Although extensive research has been focused on PRRSV, the structure and function of some viral proteins like nonstructural protein...
ORGANISM(S): Homo sapiens (Human) 
2016-06-27 | PXD004003 | Pride
Label free proteomics Hp-prrsv Nsp12 Hsp70 Inhibitor study Interactome 
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