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TranscriptomicsGenome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation [human data]
Endogenous bioelectric signaling via changes in cellular resting potential (Vmem) is a key regulator of patterning during regeneration and embryogenesis in numerous model systems. Depolarization of Vmem has been functionally implicated in de-differentiation, tumorigenesis, anatomical re-specificatio...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-72098 | biostudies-arrayexpress
TranscriptomicsBcl11b maintains quiescent mammary repopulating units
This gene expression microarray analysis is to test how induced Bcl11b expression affect the overall gene expression profile of Comma D Beta Cells in the progenitor (sca1+) and differentiated (Sca1-) population. Comma D beta Cell line was cultured DMEM F12+2% FBS+1% PSA+5ug/ml insulin+10ng/ml EGF in...
ORGANISM(S): Mus musculus 
2015-03-30 | E-GEOD-62059 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse intestinal epithelial m-ICcl2 cells stimulated with lipopolysaccharide
m-ICcl2 cells (Bens et al., Am. J. Physiol., 1996) were grown for 6 days on collagen coated cell culture flasks in medium as recommended (see ference above). Medium was changed every 48 hours. The cells were mycoplasma tested (PCR) and found negative. The medium and PBS was endotoxin tested (ELISA) ...
ORGANISM(S): Mus Musculus 
2011-08-26 | E-MTAB-355 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Soas-2 cells infected with adenoviruses expressing p53 proteins with charge-neutralizing or charge-inverting mutations in the H1 helix to investigate the role of the dimerization interface in p53 function
To investigate the role of the dimerization interface for p53 function, we introduced modest charge-neutralizing (R181→L "EL") and more severe charge-inverting (R181→E "EE" and E180→R, R181→E "RE") mutations into the H1 helix of the full-length p53 molecule. To characterize t...
ORGANISM(S): Homo sapiens 
2010-04-01 | E-MEXP-1209 | biostudies-arrayexpress
MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
TranscriptomicsTranscription profiling by array of hMADS cells transfected with miR-26a
Human multipotent adipose-derived stem (hMADS) cells were transfected at confluence with miR-26a or miR-C (non-targeting control microRNA) and cells were harvested two days later (=d0) to identify mRNAs that are downregulated by miR-26a versus miR-C, as such mRNAs could be direct miR-26a targets.
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MARS-28 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of hMADS cells transfected with miR-26a and induced to differentiate into adipocytes
Human multipotent adipose-derived stem (hMADS) cells were transfected at confluence with miR-26a or miR-C (non-targeting control microRNA). Two days later (=d0), adipocyte differentiation was induced. At d9 after start of differentiation, cells were harvested to identify mRNAs that are down- and upr...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MARS-29 | biostudies-arrayexpress
Transcriptomicscardiomyocyte induced from fibroblast
the fibroblast from the skin of the mouse dorsum become the cardiomyocyte do a lot of experiment and gradually find out the best combination of the induction
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-32605 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fat samples from gastric bypass patients
Fat tissue was resected during gastric bypass surgery for management of obesity. All subjects had fasted at least 10 hours before surgery. Subjects with malignancies were excluded. No subjects were taking thiazolidinediones or steroids. None had fasting plasma glucose levels over 120 mg/ dl. One ha...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-1657 | biostudies-arrayexpress
TranscriptomicsCell of origin in AML: Susceptibility to MN1-induced transformation is regulated by the MEIS1/abdB-like HOX protein complex
The molecular mechanism defining susceptibility of normal cells to oncogenic transformation may be a valuable therapeutic target. We characterized the cell of origin and its critical pathways in MN1 leukemias. Common myeloid (CMP), but not granulocyte-macrophage progenitors (CMP) could be transforme...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-22923 | biostudies-arrayexpress
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