Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human grafted engineered skin substitutes compared with intact human
The goal of the experiment: To characterize the dynamic gene expression profile of engineered human skin in vitro and after grafting, and compare with expression profile of uninjured human skin. Bioengineered skin substitutes can facilitate wound closure in massively burned patients, but deficiencie...
ORGANISM(S): Homo sapiens 
2009-09-07 | E-GEOD-17539 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spleens of wild type mice and mutants lacking Nix, a proapoptotic BH3-only factor that is transcriptionally induced during erythropoiesis
Normal erythropoiesis requires a critical balance between proapoptotic and antipaoptotic pathways. Bcl-xl, an antiapoptotic protein is induced at end-stages of differentiation of erythroid precursors in response to erythropoietin. The details of the proapoptotic pathway and the critical proapoptotic...
ORGANISM(S): Mus musculus 
2007-11-07 | E-GEOD-7020 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse pancreas at embryonic days 14.5 and 16.5 from animals lacking beta-catenin, a mediator of Wnt signaling and a component of the cadherin-catenin epithelial adhesion complex
Beta-catenin is an essential mediator of canonical Wnt signaling and a central component of the cadherin-catenin epithelial adhesion complex. Dysregulation of beta-catenin expression has been described in pancreatic neoplasia. Newly published studies have suggested that beta-catenin is critical for ...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7430 | biostudies-arrayexpress
TranscriptomicsExpression in Duodenum of Wild type and Onecut-2 knockout mice at postnatal days 15 and 30
Ablation of the mouse gene for Onecut-2 was reported previously, but characterization of the resulting knockout mice was focused on in utero development, principally embryonic development of liver and pancreas. Here, we examine postnatal development of these Onecut-2 knockout mice, especially the c...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-18074 | biostudies-arrayexpress
TranscriptomicsGene expression programs of histologically distinct stages of prostate carcinogenesis in Nkx3.1; Pten mutant mice
Key histological and growth progression characteristics of human prostate cancer are phenocopied in mouse models that have been subjected to androgen level depletion and engineered for hemizygosity of candidate prostate cancer tumor suppressor genes Nkx3.1 and Pten. To characterize their relative tr...
ORGANISM(S): Mus musculus 
2009-10-31 | E-GEOD-15943 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of non-obese diabetic (NOD) mice with or without the scid mutation and BDC2.5 TCR gene knock-in to study T-cell mediated B-cell damage and repair
Dynamic interaction between T-cell mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mice.
ORGANISM(S): Mus musculus 
2006-10-03 | E-CBIL-18 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse colon cancers reveals large-scale deployment of embryonic gene programming in human and murine colon cancer: a new target for intervention.
Goal of the experiment: To identify and understand the overall transcriptional programming of human colorectal cancer tumors by evaluating gene expression profiles of tumors from four murine models, and comparing and contrasting these to the developing stages of the mouse embryonic colon. Experiment...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5206 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wildtype and transgenic mice that expressed either human beta1-Arg389 and beta1-Gly389 receptors, or AC5 adenyl cyclase - differential cardiac gene regulation by Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor
The beta1-adrenergic receptor (beta1AR; ADRB1) polymorphism Arg 389Gly is located in an intracellular loop and is associated with distinct human and mouse cardiovascular phenotypes. To test the hypothesis that beta1-Arg389 and beta1-Gly389 alleles could differentially couple to pathways beyond that ...
ORGANISM(S): Mus musculus 
2009-07-01 | E-GEOD-11887 | biostudies-arrayexpress
GenomicsChromatin enrichment of TRIM24, estrogen receptor and H3K4me2 in estrogen-treated and -untreated MCF7 cells
TRIM24 PHD-Bromo domains exhibit preferential binding to unmethylated H3K4 and acetylated H3K27. TRIM24 is a co-activator of estrogen receptor (ER). The results suggest that specific ER-binding sites are depleted of H3K4me2 with estrogen treatment. TRIM24 binds these sites preferentially and faci...
ORGANISM(S): Homo sapiens 
2010-09-17 | E-GEOD-24166 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MPNST cancer cells infected with G207 an oncolytic HSV
We used microarrays to identify genes regulated during oncolytic HSV infection. Oncolytic herpes simplex viruses (oHSV) are promising anticancer therapeutics. We sought to identify alterations in gene expression during oHSV infection of human cancer cells. Human malignant peripheral nerve sheath tum...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8717 | biostudies-arrayexpress
Sort   by:  
 Page size