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Proteoglycans are essential components of the cartilage extracellular matrix (ECM), with glycosaminoglycan (GAG) chains playing a crucial role in skeletal development. This study identifies a previously unknown substrate of arylsulfatase L (ARSL) a Golgi-localized enzyme. To investigate ARSL’s physi...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-15 | PXD061172 | Pride
Investigation of the impact of Arylsulfatase L (ARSL) deletion in rat chondrosarcoma (RCS) cell lines
In this study, we identified arylsulfatase L (ARSL), which is mutated in X-linked chondrodysplasia punctata (CDPX), as a Golgi-localized enzyme responsible for glycosaminoglycan (GAG) desulfation. To elucidate the cellular and molecular consequences of ARSL deficiency, we performed trasncriptome pro...
ORGANISM(S): Rattus norvegicus 
2026-08-04 | GSE301703 | GEO
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