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Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
TranscriptomicsHelminth Infection Reactivates Latent γ-herpesvirus Via Cytokine Competition at a Viral Promoter
Mammals are co-infected by multiple pathogens that interact through unknown mechanisms. We found that helminth infection, characterized by the induction of the cytokine interleukin-4 (IL-4) and the activation of the transcription factor Stat6, reactivated murine gammaherpesvirus infection in vivo. I...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-58116 | biostudies-arrayexpress
TranscriptomicsTargeted chromatin profiling reveals novel enhancers in Ig heavy and light chain loci.
Chip-chip from pro-B cells from Rag1KO mice for H3K27ac and RNA Pol II Identification of novel enhancers from Ig heavy and light chain loci Rag1KO pro-B epigenetic landscape at Ig heavy and light chain loci
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-53766 | biostudies-arrayexpress
TranscriptomicsType 1 interferons induce changes in core metabolism that are critical for immune function
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress
ProteomicsUsing FAIMS to improve tumor neoantigen detection
DDA and PRM analysis, with and without FAIMS, for the T3, F244, and 1956 MCA sarcoma cell lines. PRM analysis of MHC-I neoantigens in ex vivo mouse tumors.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-08-08 | MSV000092617 | MassIVE
Proteomics,MultiomicsElectrophilic stress induced by itaconate and its derivatives regulates ATF3-IKBZ inflammatory axis independently of Nrf2 induction
Metabolic regulation recently emerged as a novel powerful principle guiding immune responses. The natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) were recently shown to selectively inhibit a subset of cytokines during macrophage activation, yet the precise ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-25 | MSV000082101 | MassIVE
ProteomicsItaconate modulates immune responses via inhibition of peroxiredoxin 5
Wild type and Irg1 knockout mouse bone marrow derived macrophages (BMDMs) were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-01 | MSV000093232 | MassIVE
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