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GenomicsFoxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification
This SuperSeries is composed of the following subset Series: GSE40684: Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq] GSE40685: Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [Expression] Refer to in...
ORGANISM(S): Mus musculus 
2012-09-28 | E-GEOD-40686 | biostudies-arrayexpress
TranscriptomicsFoxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [Expression]
Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new ...
ORGANISM(S): Mus musculus 
2012-09-28 | E-GEOD-40685 | biostudies-arrayexpress
GenomicsFoxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq]
Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new ...
ORGANISM(S): Mus musculus 
2012-09-28 | E-GEOD-40684 | biostudies-arrayexpress
TranscriptomicsTreg specific Gata3 knock out array
The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (Treg cells). To gain insights into the molecular mechanisms of Foxp3 mediated gene expression we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric ana...
ORGANISM(S): Mus musculus 
2012-08-28 | E-GEOD-39864 | biostudies-arrayexpress
TranscriptomicsContinuous requirement for the T cell receptor for regulatory T cell function
Foxp3+ regulatory T cells (Treg cells) maintain immunological tolerance and their deficiency results in fatal multi-organ autoimmunity. Although heightened T cell receptor (TCR) signaling is critical for the differentiation of Treg cells, the role of TCR signaling in Treg cell function remains larg...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-61077 | biostudies-arrayexpress
GenomicsEBNA1 ChIP-seq and MNase-seq in EBV-positive MUTU cell lines
Epstein-Barr Virus (EBV), which is associated with multiple human tumors, persists as a minichromosome in the nucleus of B-lymphocytes and induces malignancies through incompletely understood mechanisms. Here, we present a large-scale functional genomic analysis of EBV. Our experimentally generated ...
ORGANISM(S): Human Herpesvirus 5 
2012-08-28 | E-GEOD-39913 | biostudies-arrayexpress
TranscriptomicsInferring transcriptional and microRNA-mediated regulatory programs in glioblastoma
Large-scale cancer genomics projects are profiling hundreds of tumors at multiple molecular layers, including copy number, mRNA and miRNA expression, but the mechanistic relationships between these layers are often excluded from computational models. We developed a supervised learning framework for...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-GEOD-32876 | biostudies-arrayexpress
GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
GenomicsInflammation induced repression of Foxp3-bound chromatin in regulatory T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-04-12 | E-GEOD-55753 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of wild type and CNS2-deficient Treg cells in the resting state
Resting regulatory T cells (CD4+GFP+CD44lowCD62Lhigh) were sorted from the littermates of male Foxp3gfp and Foxp3ΔCNS2-gfp mice. Poly(A)-tailed RNA were amplified and sequenced on an Ion Torrent platform. RNA-seq of WT and CNS2KO regulatory T cells in the resting state
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-58905 | biostudies-arrayexpress
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