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GenomicsActivation of feedforward wiring in adult hippocampal neurons by the bHLH transcription factor Ascl4
Activation of feedforward wiring in adult hippocampal neurons by the bHLH transcription factor Ascl4
PRJNA1034945 | ENA
TranscriptomicsActivation of feedforward wiring in adult hippocampal neurons by the bHLH transcription factor Ascl4
Although evidence indicates that the adult brain retains a considerable capacity for circuit formation, adult wiring has not been broadly considered and remains poorly understood. Here, we investigated wiring activation in adult neurons. Based on bioinformatic analyses on a previously published data...
ORGANISM(S): Mus musculus 
2024-05-09 | GSE246825 | GEO
ProteomicsShared proteomic and transcriptomic signatures of molecularly-induced feedback and feedforward wiring of adult hippocampal neurons
Molecular programming by basic helix-loop-helix (bHLH) proteins can potently reactivate axon growth in adult neurons, enabling the investigation of the mechanisms and the potentials of adult brain rewiring. Here, we focused on the mechanisms by studying proteomic and transcriptomic changes during Id...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-28 | PXD052336 | Pride
Dentate gyrus Rewiring Id2 Ascl4 
UnknownPDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration.
Not available
S-EPMC11787312 | biostudies-literature
UnknownACSL4 is essential for radiation-induced intestinal injury by initiating ferroptosis.
Not available
S-EPMC9307849 | biostudies-literature
TranscriptomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids [PS-ac-peptide]
Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-Oxi...
ORGANISM(S): Homo sapiens 
2022-05-31 | GSE201052 | GEO
TranscriptomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids [STAT3]
Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-Oxi...
ORGANISM(S): Homo sapiens 
2022-05-31 | GSE201051 | GEO
UnknownAPOBEC-1 deletion enhances cisplatin-induced acute kidney injury.
Not available
S-EPMC10721635 | biostudies-literature
UnknownMLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis.
Not available
S-EPMC11663353 | biostudies-literature
MetabolomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-...

2022-05-31 | MTBLS4709 | MetaboLights
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