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TranscriptomicsId2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We ...
ORGANISM(S): Mus musculus 
2014-06-29 | E-GEOD-57682 | biostudies-arrayexpress
TranscriptomicsGene-expression profile of Id2+ versus Id2KO KLRG1lo cells during infection
CD8+ T cells play a crucial role in the clearance of intracellular pathogens through the generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells that provide enhanced protection against reinfection. We have previously shown that the inhibitor of E protein tra...
ORGANISM(S): Mus musculus 
2013-03-07 | E-GEOD-41978 | biostudies-arrayexpress
TranscriptomicsWhole genome mRNA analysis of virus-specific CD8+ T cells expressing different levels of Id2-GFP following influenza virus infection
We speculated that distinct levels of Id2 was deterministic in the transcriptional program of antigen-specific CD8+ T cells. To test this hypothesis, we subjected DbNP366-specific effector CD8+ T cells purified according to their differential expression of Id2-GFP (Id2-GFPint and Id2-GFPhigh) to mic...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-44140 | biostudies-arrayexpress
TranscriptomicsWhole genome mRNA analysis of wild-type and Id2-deficient virus-specific CD8+ T cells after influenza infection
The transcription factor Inhibitor of DNA binding 2 (Id2) modulates T cell fate decisions but the molecular mechanism underpinning this regulation is unclear. Here, using whole genome mRNA analysis we show that loss of Id2 programs CD8+ T cells to adopt a memory fate with increased Eomesodermin and ...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-44141 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in the embryonic midgut of Id2 knockout and wild-type mice
Id2 knockout mice develop heterotopic gastric tissues in the small intestine during development. To gain a mechanistic insight into the cell fate conversion in the Id2 knockout midgut endoderm, we performed microarray analysis using RNA samples extracted from midgut tissues at E13.5. We analyzed the...
ORGANISM(S): Mus musculus 
2015-07-04 | E-GEOD-43014 | biostudies-arrayexpress
TranscriptomicsPDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.
Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma. Total...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77423 | biostudies-arrayexpress
TranscriptomicsPDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.
Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma. Total...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77419 | biostudies-arrayexpress
TranscriptomicsRNA sequencing analysis of murine MLL-AF9 acute myeloid leukemia cells expressing different levels of Id2 and Kit
We investigated the role of the transcriptional regulator Id2 in the context of MLL-rearranged acute myeloid leukemia (AML). Using an Id2/GFP-reporter mouse model of MLL-AF9-driven AML, we showed that Id2 is expressed heterogeneously across the leukemic population. Moreover, differential expression ...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-68461 | biostudies-arrayexpress
TranscriptomicsRNA sequencing expression analysis of murine Tet-off MLL-AF9;NRAS acute myeloid leukemia cells over-expressing Id2 and upon MLL-AF9 withdrawal
We investigated the role of the transcriptional regulator Id2 in the context of MLL-rearranged acute myeloid leukemia (AML). Using an AML mouse model driven by tet-regulated MLL-AF9 co-expressed with oncogenic NRASG12D (Tet-off MLL-AF9), we demonstrated that MLL-AF9 regulates the E protein pathway b...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-68462 | biostudies-arrayexpress
TranscriptomicsA genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.
It is now well established that the E- and Id-protein axis regulates multiple steps in lymphocyte development. However, it remains unknown as to how E- and Id-proteins mechanistically enforce and maintain the naïve T cell fate. Here we show that Id2 and Id3 suppressed the development and expansion o...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64779 | biostudies-arrayexpress
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