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ProteomicsEpigenetic-focused CRISPR-Cas9 screen identifies ASH2L as a regulator of Glioblastoma cell survival
Glioblastoma Multiforme (GBM) is the most common and aggressive primary brain tumor. Despite recent developments in surgery, chemo- and radiotherapy, a currently poor prognosis of GBM patients highlights an urgent need for novel treatment strategies. Our awareness on importance of epigenetic mechani...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD033358 | Pride
Ash2l Glioblastoma Crisper-cas9 
GenomicsMouse ESCs (ES-D3) with Ash2l depletion
Mouse ESCs (ES-D3) with Ash2l depletion
PRJNA563897 | ENA
GenomicsDiscrete chromatin alterations and deregulated gene expression upon PROTAC-induced rapid loss of the trithorax protein ASH2L [ChIP-seq(Ash2l)]
Discrete chromatin alterations and deregulated gene expression upon PROTAC-induced rapid loss of the trithorax protein ASH2L [ChIP-seq(Ash2l)]
PRJNA1006023 | ENA
GenomicsThe KMT2 complex protein ASH2L controls meiosis through silencing transposon
The KMT2 complex protein ASH2L controls meiosis through silencing transposon
PRJNA1032460 | ENA
GenomicsConsequences of a loss of Ash2l in the bone marrow.
Consequences of a loss of Ash2l in the bone marrow.
PRJNA471336 | ENA
UnknownAsh2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network.
Not available
S-EPMC6821267 | biostudies-literature
UnknownFunctional role of Ash2l in oxLDL induced endothelial dysfunction and atherosclerosis.
Not available
S-EPMC10821849 | biostudies-literature
GenomicsMouse ESCs (ES-D3) with Ash2l depletion
We showed a novel mechanism in which Ash2l directly binds to super-enhancers of several stemness genes to regulate pluripotency and self-renewal in pluripotent stem cells. Ash2l recruits Oct4/Sox2/Nanog (OSN) to form Ash2l/OSN complex at the super-enhancers of Jarid2, Nanog, Sox2, and Oct4, and furt...
ORGANISM(S): Mus musculus 
2020-01-24 | GSE136870 | GEO
GenomicsASH2L controls ureteric bud morphogenesis via regulation of RET/GFRA1 signaling activity [CUT&Tag]
ASH2L controls ureteric bud morphogenesis via regulation of RET/GFRA1 signaling activity [CUT&Tag]
PRJNA859014 | ENA
GenomicsCOMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling
COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling
PRJNA495171 | ENA
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