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ProteomicsDeletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation
In the healing process of myocardial infarction, cardiac fibroblasts are activated to produce collagen, leading to adverse remodeling and heart failure. Our previous study showed that ASPP1 promotes cardiomyocyte apoptosis by enhancing nuclear trafficking of p53. We thus explored the influence of AS...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-18 | PXD055651 | Pride
Lc-ms Primary mouse cardiac fibroblasts Aspp1 
TranscriptomicsAspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation
Quiescent hematopoietic stem cells (HSCs) are prone to mutagenesis, and accumulation of mutations can result in hematological malignancies. The mechanisms through which HSCs prevent such detrimental accumulation, however, are unclear. Here, we show that Aspp1 coordinates with p53 to maintain the gen...
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-69032 | biostudies-arrayexpress
TranscriptomicsAspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation
Quiescent hematopoietic stem cells (HSCs) are prone to mutagenesis, and accumulation of mutations can result in hematological malignancies. The mechanisms through which HSCs prevent such detrimental accumulation, however, are unclear. Here, we show that Aspp1 coordinates with p53 to maintain the gen...
ORGANISM(S): Mus musculus 
2015-05-20 | GSE69032 | GEO
UnknownDeletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation.
Not available
S-EPMC11439048 | biostudies-literature
UnknownASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer.
Not available
S-EPMC7142079 | biostudies-literature
GenomicsMus musculus
Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation
PRJNA284343 | ENA
UnknownMolecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.
Not available
S-EPMC2532732 | biostudies-literature
UnknownEvaluation of apoptosis stimulating protein of TP53-1 (ASPP1/PPP1R13B) to predict therapy resistance and overall survival in acute myeloid leukemia (AML).
Not available
S-EPMC10776670 | biostudies-literature
UnknownASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells.
Not available
S-EPMC3595493 | biostudies-literature
UnknownASPP1/2 positive patients with invasive breast cancers have good prognosis
Not available
S-EPMC10597814 | biostudies-literature
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