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TranscriptomicsVAPB regulates proliferation in medulloblastoma
RNA sequencing of medulloblastoma cell lines DAOY and USP13-med; wild type and VAPB KO.
ORGANISM(S): Homo sapiens 
2023-06-28 | E-MTAB-11914 | biostudies-arrayexpress
ProteomicsMesenchymal stem cells enhance tumorigenic properties of human glioblastoma cells through independent cell-cell communication mechanisms
Mesenchymal stem cells (MSC) display tumor tropism and have been addressed as vehicles for delivery of anti-cancer agents. As cellular components of the tumor microenvironment, MSC also influence tumor progression. However, the contribution of MSC in brain cancer is not well understood since either ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-13 | PXD008035 | Pride
Aggressiveness Mesenchymal stem cells Glioblastoma Tumor microenvironment 
ProteomicsMesenchymal Stromal Cells: What are the secrets of their secretome?
Multipotent Mesenchymal Stromal Cells (MSCs) are multipotent adult cells that can be isolated from different tissues. The current hypothesis supports that the main MSCs action mechanism relates to its paracrine activity, creating a microenvironment with trophic signals. However, preclinical studies ...
ORGANISM(S): Homo sapiens (Human) 
2016-12-09 | PXD003978 | Pride
Mesenchymal stromal cells Proteome Secretome 
ProteomicsIFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis type 6 (ALS6) is a familial subtype of ALS linked to Fused in Sarcoma (FUS) gene mutation. FUS mutations lead to decreased global protein synthesis, but the mechanism that drives this has not been established. Here, we used ALS6 patient-derived induced pluripotent stem ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038042 | Pride
Als  als6  fus  protein synthesis  ifny 
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