Sort   by:  
 Page size 
ProteomicsMice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties
Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with ASTN2 mutations exhibit neurodevelopmental disorders, including autism spectrum disorder...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-30 | PXD052868 | Pride
Astn2 Purkinje cell Neurodevelopmental disorder Cerebellum Autism spectrum disorder 
GenomicsMice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties
Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties
PRJNA1069039 | ENA
TranscriptomicsMice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties
Astrotactin 2 (ASTN2) is a transmembrane, neuronal protein that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. We recently reported a family with a paternally inherited intragenic ASTN2 duplication, with a range of neurodevelopmental disorders, inclu...
ORGANISM(S): Mus musculus 
2024-03-07 | GSE254224 | GEO
GenomicsAnalysis of human neuronal cells carrying ASTN2 deletion: A cross-disorder risk variant of psychiatric disorders
Analysis of human neuronal cells carrying ASTN2 deletion: A cross-disorder risk variant of psychiatric disorders
PRJNA1082745 | ENA
TranscriptomicsAnalysis of human neuronal cells carrying ASTN2 deletion: A cross-disorder risk variant of psychiatric disorders
Recent genetic studies have found common genomic risk variants among psychiatric disorders, strongly suggesting the overlaps in their molecular and cellular mechanism. Our research group identified the variant in ASTN2 as one of the candidate risk factors across these psychiatric disorders by whole-...
ORGANISM(S): Homo sapiens 
2024-03-07 | GSE260713 | GEO
UnknownASTN2 modulates synaptic strength by trafficking and degradation of surface proteins.
Not available
S-EPMC6187130 | biostudies-literature
UnknownAnalysis of human neuronal cells carrying ASTN2 deletion associated with psychiatric disorders.
Not available
S-EPMC11148150 | biostudies-literature
UnknownMice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties.
Not available
S-EPMC11348334 | biostudies-literature
UnknownMice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties.
Not available
S-EPMC10888872 | biostudies-literature
UnknownSingle-Cell Sequencing Analysis Identified ASTN2 as a Migration Biomarker in Adult Glioblastoma.
Not available
S-EPMC9688571 | biostudies-literature
Sort   by:  
 Page size