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TranscriptomicsPooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma
We performed a pooled GWAS and individual genotyping in 269 children with allergic respiratory diseases comparing allergic children with and without asthma. We used a modular approach to identify the most significant loci associated with asthma by combining silhouette statistics and physical distanc...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-24481 | biostudies-arrayexpress
TranscriptomicsCopy number data from GIST with KIT mutation
In addition to KIT and PDGFRA mutations, sequential accumulation of other genetic events is involved in the development and progression of gastrointestinal stromal tumors (GISTs). Until recently, the significance of these other alterations has not been thoroughly investigated. The combination of gen...
ORGANISM(S): Homo sapiens 
2010-08-27 | E-GEOD-20709 | biostudies-arrayexpress
TranscriptomicsInhibition of MYCN by a PNA anti-gene in alveolar rhabdomyosarcoma
The objective was to identify the molecular mechanisms responsible for in vitro and in vivo efficacy of an anti-MYCN peptide nucleic acid on a preclinical model of alveolar rhabdomyosarcoma. Cells treated with a anti-MYCN PNA exhibit growth arrest and apoptosis, and in vivo tumor growth is blocked. ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-7959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cultured rat cardiomyocytes grown with eicosapentaenoic acid or docosahexaenoic acid supplementation in the culture media
Despite the recognized protective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cardiovascular diseases, and the demonstration of the control of gene expression by polyunsaturated fatty acids (PUFAs), the effects of these n-3 fatty acids on the whole genoma has never been ...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-4327 | biostudies-arrayexpress
TranscriptomicsExpression data from post mortem porcine skeletal muscle
We set up a pilot study using Affymetrix Gene Chip® Porcine Genome Arrays to evaluate the impact of time lags from death on gene expression profiling of porcine skeletal muscle at four post mortem time points (up to 24 hrs) during the routine processing of fresh tights Post mortem skeletal muscle sa...
ORGANISM(S): Sus scrofa 
2011-01-19 | E-GEOD-26701 | biostudies-arrayexpress
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