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GenomicsTranscriptional impact of EGFR-AT1R-crosstalk (Stable transfection of AT1R in HEK293 cells)
Transcriptional impact of EGFR-AT1R-crosstalk (Stable transfection of AT1R in HEK293 cells)
PRJNA682997 | ENA
GenomicsTranscriptional impact of EGFR-AT1R-crosstalk (Transient transfection of AT1R in HEK293 cells)
Transcriptional impact of EGFR-AT1R-crosstalk (Transient transfection of AT1R in HEK293 cells)
PRJNA682998 | ENA
ProteomicsMapping AT1R biased signaling using proximity-labeling and proteomics identifies diverse actions of biased agonists
Angiotensin II type 1 receptors (AT1Rs) are one of the most widely studied G protein-coupled receptors. To fully appreciate the diversity in cellular signaling profiles activated by AT1R transducer-biased ligands, we utilized peroxidase-catalyzed proximity labeling to capture proteins in close prox...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD023814 | Pride
Apex Proximity labeling At1r Biased agonism 
TranscriptomicsRole of redox-dependent, flow-related regulation of AT1R expression in collateral growth impairment
Genomic analysis of control and collateral arteries was used to investigate mechanisms responsible for impaired collateral growth in the Spontaneously Hypertensive rat, an animal model of essential hypertension with increased oxidative and nitrosative stress and metabolic abnormalities. A fundament...
ORGANISM(S): Rattus norvegicus 
2010-12-15 | E-GEOD-19524 | biostudies-arrayexpress
ProteomicsPhosphorylation patterns on the c-terminal tail of the angiotensin II type 1 receptor encode differential signaling pathways
Structural studies have recently shown that mechanism of selective AT1R activation by different classes of ligands is initiated by the ability of ligands to stabilize unique active conformations of the receptor. Active conformations enhance transducer coupling leading to effector mediated signaling...
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD032672 | Pride
Trv023 At1r Tmt-ms Angiotensin ii Β-arrestin 
TranscriptomicsTranscriptional impact of EGFR-AT1R-crosstalk (Transient transfection of AT1R in HEK293 cells)
The impact of AT1R and EGFR on SRF transcriptional activity, signaling pathways and transcriptome regulation were investigated in HEK293, HK-2 and vascular smooth muscle cells, applying reporter gene, protein and mRNA expression techniques as well as RNAseq followed by bioinfor-matic analysis.
ORGANISM(S): Homo sapiens 
2022-01-10 | GSE162769 | GEO
TranscriptomicsTranscriptional impact of EGFR-AT1R-crosstalk (Stable transfection of AT1R in HEK293 cells)
The impact of AT1R and EGFR on SRF transcriptional activity, signaling pathways and transcriptome regulation were investigated in HEK293, HK-2 and vascular smooth muscle cells, applying reporter gene, protein and mRNA expression techniques as well as RNAseq followed by bioinfor-matic analysis.
ORGANISM(S): Homo sapiens 
2022-01-10 | GSE162768 | GEO
UnknownAltered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation.
Not available
S-EPMC3141779 | biostudies-literature
UnknownInterplay of cholesterol, membrane bilayers and the AT1R: A cholesterol consensus motif on AT1R is revealed.
Not available
S-EPMC7758360 | biostudies-literature
GenomicsTranscriptional impact of EGFR-AT1R-crosstalk
Transcriptional impact of EGFR-AT1R-crosstalk
PRJNA682993 | ENA
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