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TranscriptomicsAnalysis of the expression of Ataxin-2-target genes
We recently identified the RNA targets of Ataxin-2 by using PAR-CLIP. To elucidate the functional role of Ataxin-2 on target-binding, we have knocked down or overexpressed Ataxin-2 in HEK293T cells and extracted RNAs 48 hrs after transfection. Then, these total RNAs were subjected to whole transcrip...
ORGANISM(S): Homo sapiens 
2014-06-20 | E-GEOD-53189 | biostudies-arrayexpress
ProteomicsAtxn2-Knock-Out mice show branched chain amino acids and fatty acids pathway alterations
Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes mellitus type 1 and hypertension in genome-wide association studies, while mouse studies showed the knock-out of Atxn2 to lead to obesity, insulin resistance and dyslipidemia. Intriguingly, the deficiency of ATXN2...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-07 | MSV000084933 | MassIVE
ProteomicsAnalysis of Ataxin-2 interactome using LC-MS/MS
We analyzed Ataxin-2 interactome using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). HEK293T cell lysate was subjected to immunoprecipitation (IP) with either anti-Ataxin-2 antibody or control IgG. The interaction between Ataxin-2 and the copurified proteins do not appear t...
ORGANISM(S): Homo sapiens (Human) 
2021-03-22 | PXD024350 | Pride
Human Lc-msms Ataxin-2 
GenomicsAtaxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila
Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila
PRJNA769137 | ENA
GenomicsTargeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
PRJNA825077 | ENA
GenomicsAntagonistic roles for Ataxin-2 structured and disordered domains in RNP condensatation
Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensatation
PRJNA644650 | ENA
TranscriptomicsAnalysis of the expression of Ataxin-2-target genes
We recently identified the RNA targets of Ataxin-2 by using PAR-CLIP. To elucidate the functional role of Ataxin-2 on target-binding, we have knocked down or overexpressed Ataxin-2 in HEK293T cells and extracted RNAs 48 hrs after transfection. Then, these total RNAs were subjected to whole transcrip...
ORGANISM(S): Homo sapiens 
2014-06-20 | GSE53189 | GEO
TranscriptomicsAtaxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth
Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder, which is caused by an unstable CAG-repeat expansion in the SCA2 gene, that encodes a polyglutamine tract (polyQ-tract) expansion in ataxin-2 protein (ATXN2). The RNA-binding protein ATXN2 interacts with the poly(A)-binding protein...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-55177 | biostudies-arrayexpress
TranscriptomicsAntagonistic roles for Ataxin-2 structured and disordered domains in RNP condensatation
Ataxin-2 is a conserved translational control protein as well as an important target for ALS therapeutics under development. Despite its clinical and biological significance, Ataxin-2’s activities, mechanisms and functions are not well understood. Using Drosophila Ataxin-2 (Atx2) we investigate how ...
ORGANISM(S): Drosophila melanogaster 
2021-03-03 | GSE153985 | GEO
TranscriptomicsTargeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
Gene-based therapeutic strategies to lower ataxin-2 levels are emerging for neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia type 2 (SCA2). To identify additional ways of reducing ataxin-2 levels, we performed a genome-wide screen in human cells for regulator...
ORGANISM(S): Homo sapiens 
2022-10-18 | GSE200530 | GEO
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