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ProteomicsSpic a specific marker of ground state pluripotency that regulates one carbon metabolism
Understanding mechanisms of epigenetic regulation in embryonic stem cells (ESCs) is of fundamental importance for stem cell and developmental biology. Here we identify Spic, a member of the ETS family of transcription factors, as a specific marker of ground state pluripotency. We show that Spic is r...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039213 | Pride
Spic Sam Embryonic stem 2il One carbone metabolism Epigenetic Ground state Bhmt 
ProteomicsThe translational landscape of naïve and primed state pluripotency
Translational control plays a central role in regulation of gene expression and can lead to significant divergence between mRNA- and protein-abundance. The translational landscape of early mammalian development and its impact on cellular proteome, however, remains largely un-explored. Here we used g...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-03 | PXD014528 | Pride
Ribosome profiling Proteome Translation Embryonic stem cells Ground state pluripotency 
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