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ProteomicsSpic a specific marker of ground state pluripotency that regulates one carbon metabolism
Understanding mechanisms of epigenetic regulation in embryonic stem cells (ESCs) is of fundamental importance for stem cell and developmental biology. Here we identify Spic, a member of the ETS family of transcription factors, as a specific marker of ground state pluripotency. We show that Spic is r...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039213 | Pride
Spic Sam Embryonic stem 2il One carbone metabolism Epigenetic Ground state Bhmt 
TranscriptomicsHeme-induced inhibition of Bach1derepresses Spic.
Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor Spic is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the...
ORGANISM(S): Mus musculus 
2014-03-14 | E-GEOD-53796 | biostudies-arrayexpress
UnknownCohort profile of the ICMR-Stillbirth Pooled India Cohort (ICMR-SPIC): estimating prevalence, analysing risk factors and developing prediction models for stillbirths in India.
Not available
S-EPMC12382554 | biostudies-literature
GenomicsSpic is required for the differentiation of metaphocyte progenitor cells
Spic is required for the differentiation of metaphocyte progenitor cells
PRJNA951376 | ENA
TranscriptomicsHeme-induced inhibition of Bach1derepresses Spic.
Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor Spic is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the...
ORGANISM(S): Mus musculus 
2014-03-14 | GSE53796 | GEO
TranscriptomicsHeme regulates the development of iron-recycling macrophages from monocytes (sorted splenocytes)
Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor Spic is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the...
ORGANISM(S): Mus musculus 
2014-03-14 | E-GEOD-46984 | biostudies-arrayexpress
Genomics(RNA-seq) Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency
(RNA-seq) Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency
PRJNA917519 | ENA
Genomics(ATAC-seq_and_ChIP-seq) Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency
(ATAC-seq_and_ChIP-seq) Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency
PRJNA917523 | ENA
TranscriptomicsSpic is required for the differentiation of metaphocyte progenitor cells
Metaphocytes are tissue-resident myeloid-like cells of non-hematopoietic origin in zebrafish barrier tissues. How metaphocytes acquire myeloid cell properties from non-hematopoietic precursors during the development remains unknown. Here we show that metaphocytes are in situ generated from local pro...
ORGANISM(S): Danio rerio 
2023-04-08 | GSE228732 | GEO
Transcriptomics(RNA-seq) Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency
Understanding mechanisms of epigenetic regulation in embryonic stem cells (ESCs) is of fundamental importance for stem cell and developmental biology. Here we identify Spic, a member of the ETS family of transcription factors, as a specific marker of ground state pluripotency. We show that Spic is r...
ORGANISM(S): Mus musculus 
2023-09-06 | GSE222053 | GEO
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