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MetabolomicsInsights into the stereochemical mechanism of the B12-dependent radical SAM glutamine C- methyltransferases QCMT
Methyl-coenzyme M reductase (MCR) is a crucial enzyme for methanogenesis and harbors several unusual post-translational modifications. Recent studies have identified glutamine C-methyltransferase (QCMT), as a B12-dependent radical SAM enzyme responsible for methylating a glutamine residue within the...
2026-04-28 | MTBLS14287 | MetaboLights
GenomicsStaphylococcus aureus LCT-SAM
Staphylococcus aureus LCT-SAM Genome sequencing and assembly
PRJNA235250 | ENA
ProteomicsTGF-β1/p65/MAT2A: a novel pathway involved in the regulation of intracellular SAM and liver fibrogenesis - Part2
Hepatic stellate cell (HSC) activation induced by transforming growth factor β (TGF-β1) plays a pivotal role in the fibrogenesis. The complex downstream mediators of TGF-β1 are largely unknown. Here, proteomics analysis and biological validation demonstrated that methionine adenosyltransferase 2A (M...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD011135 | Pride
Proteomics liver fibrosis mat2a 
GenomicsStaphylococcus aureus strain:SAM-1
Staphylococcus aureus strain:SAM-1 Genome sequencing and assembly
PRJNA437716 | ENA
GenomicsStenotrophomonas sp. SAM-B
Stenotrophomonas sp. SAM-B Genome sequencing and assembly
PRJNA627094 | ENA
TranscriptomicsComparison of the transcription (coding and lncRNAs) of in vitro cultured bovine SAM-treated blastocysts and non-treated blastocysts
Transcriptome (total RNA) profiling of bovine in vitro cultured expanded blastocysts (EB) comparing control non-treated expanded blastocysts with SAM-treated expanded blastocysts. S-Adenosyl methionine (SAM) is the global methyl donor providing methyl group for variety of biomolecules such as DNA , ...
ORGANISM(S): Bos taurus 
2016-02-29 | E-GEOD-75430 | biostudies-arrayexpress
MetabolomicsThe GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis
Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue specific methyltransferases regulates methylation potential. Among them,...
2026-08-18 | MTBLS15161 | MetaboLights
ProteomicsSulfur assimilation improves SAM-dependent methylation
We employed omic data and conducted comparative analysis in Saccharomyces cerevisiae strains with different S-adenosine-L-methionine (SAM) level. This strategy can help us locate the limiting factor for SAM availability. We found sulfur assimilation emerged as the most significantly enriched pathway...
ORGANISM(S): Saccharomyces Cerevisiae 
2025-07-23 | PXD066499 |
TranscriptomicsS-adenosylmethionine modifies cocaine-induced DNA methylation and increases locomotor sensitization in mice
The aim of the study was to investigate whether environmental factors like S-adenosylmethionine (SAM) via affecting epigenome could alter cocaine-induced gene expression and locomotor sensitization in mice. Using mouse nucleus accumbens (NAc) tissue, whole-genome gene expression profiling revealed t...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48365 | biostudies-arrayexpress
ProteomicsLong noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly
Long non-coding RNAs (lncRNAs) are family of gene regulators but the functional study of lncRNAs in skeletal muscle satellite cells (SCs) remains at the infancy stage. Here we identify SAM (Sugt1 associated muscle) lncRNA (also known as Snhg15, (small nucleolar RNA host gene 15) that is enriched in ...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-18 | PXD018147 | Pride
Lc-ms 
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