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ProteomicsTargeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication.
De Antonellis et al. shows the importance of the Ca2+ channel pump ATP2B1 in the regulation of intracellular Ca2+ levels that positively influence SARS-CoV-2 replication in human cells. Our study identifies the mechanism of action of SARS-CoV-2 in the regulation of the expression of ATP2B1 and ATP2A...
ORGANISM(S): Homo sapiens (Human) 
2024-05-17 | PXD051059 | Pride
Pi3k/akt Sars-cov-2 Atp2a1 Atp2b1 Ca2+ Forkhead box (fox) transcription factor Endoplasmic reticulum 
GenomicsATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity
ATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity
PRJNA1297734 | ENA
GenomicsATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity
Long-term hematopoietic stem cells (LT-HSC) maintain lifelong hematopoiesis while preserving the stem cell compartment through self-renewal. The human LT-HSC compartment is molecularly and functionally heterogeneous and also varies across ontogeny. Dissecting the molecular basis for this variation i...
ORGANISM(S): Homo sapiens 
2026-04-17 | GSE303822 | GEO
UnknownDe novo variants in ATP2B1 lead to neurodevelopmental delay.
Not available
S-EPMC9118097 | biostudies-literature
UnknownBiallelic ATP2B1 variants as a likely cause of a novel neurodevelopmental malformation syndrome with primary hypoparathyroidism.
Not available
S-EPMC10772071 | biostudies-literature
UnknownTargeting ATP2B1 impairs PI3K/Akt/FOXO signaling and reduces SARS-COV-2 infection and replication.
Not available
S-EPMC11239940 | biostudies-literature
UnknownATP2B1-AS1 Promotes Cerebral Ischemia/Reperfusion Injury Through Regulating the miR-330-5p/TLR4-MyD88-NF-κB Signaling Pathway.
Not available
S-EPMC8545896 | biostudies-literature
UnknownCYP17A1-ATP2B1 SNPs and Gene-Gene and Gene-Environment Interactions on Essential Hypertension.
Not available
S-EPMC8552967 | biostudies-literature
UnknownThe Calcium Pump ATP2B1/PMCA1 Regulates CNS Vascular Development by Facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling.
Not available
S-EPMC12330718 | biostudies-literature
UnknownLow expression and Hypermethylation of ATP2B1 in Intrahepatic Cholangiocarcinoma Correlated With Cold Tumor Microenvironment.
Not available
S-EPMC9302110 | biostudies-literature
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