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TranscriptomicsDynamic Ca2+-dependent transcription links metabolic stress to impaired β-cell identity
Sustained stimulation and elevations in intracellular Ca2+ concentrations due to metabolic stress in pre-diabetic states triggers gene expression changes contributing to the loss of pancreatic β-cell function. To establish a temporal relationship between β-cell stimulation and perturbations in Ca2+...
ORGANISM(S): Mus musculus 
2025-05-22 | E-MTAB-14642 | biostudies-arrayexpress
GenomicsStaphylococcus lentus Ca2
Staphylococcus lentus Ca2 genome sequence
PRJEB278 | ENA
TranscriptomicsTranscription profiling of fertilized mouse eggs reveals Ca2+ oscillatory pattern in fertilized mouse eggs affects gene expression and development to term.
The Ca2+ oscillations initiated by the fertilizing sperm (but terminating concomitant with pronucleus formation) apparently ensure that the events constituting egg activation occur in the correct temporal order; early events (e.g., cortical granule exocytosis) require fewer oscillations than later e...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11687 | biostudies-arrayexpress
TranscriptomicsTranscription profilfing of human cerebrovascular smooth muscle to identify Ca2+-dependent transcription patterns
Altered Ca2+ handling has both immediate physiological effects and long-term genomic effects on vascular smooth muscle function. Previously we have shown that elevation of cytoplasmic Ca2+ through voltage-dependent Ca2+ channels (VDCCs) or store-operated Ca2+ channels (SOCCs) results in phosphoryla...
ORGANISM(S): Homo sapiens 
2009-04-29 | E-GEOD-2883 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monoclonal cell lines with high or low levels of store-operated Ca2+ entry
This series of microarray experiments monitored the gene expression profiles for monoclonal cell lines (derived from HEK-293 parental cell culture) with high (H1, H15, H24, H36, H39) or low (L3, L28, L29) levels of store-operated Ca2+ entry (SOCE). For selection of clones, HEK-293 cells were loaded ...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1309 | biostudies-arrayexpress
TranscriptomicsHuman CA2 ES cells undergoing stepwise differentiation to airway epithelium and challenged with TNFa and LPS
This study examines the innate immune response of human pluripotent stem cell derived airway epithelium. Immune challenge was performed with TNF-alpha or bacterial lipopolysaccharide (LPS) Airway epithelium differentiated from the ES line CA2 was compared to paired differentiated cells stimulated wi...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-59472 | biostudies-arrayexpress
GenomicsHymenobacter cheonanensis strain:CA2-7
Hymenobacter cheonanensis strain:CA2-7 Genome sequencing and assembly
PRJNA997743 | ENA
ProteomicsAltered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation
GM1-ganglioside, an abundant GSL in neuronal membranes, is integral to ER-PM junctions where it interacts with synaptic proteins/receptors and regulates Ca2+ signaling.
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD042994 | Pride
Membrane contact sites (mcs) Glycosphingolipids (gsls) Proteomics 
GenomicsHelicobacter pylori strain:CA2
Helicobacter pylori strain:CA2 Genome sequencing and assembly
PRJNA563769 | ENA
UnknownCa2+ tunneling architecture and function are important for secretion.
Not available
S-EPMC11540855 | biostudies-literature
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