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MetabolomicsIntegrated gut microbiome and lipidomic analyses in animal models of Wilson disease reveal a role of intestine ATP7B in copper-related metabolic dysregulation (Part 1)
Not available
ORGANISM(S): Mus musculus 
ST002423 | MetabolomicsWorkbench
MetabolomicsIntegrated gut microbiome and lipidomic analyses in animal models of Wilson disease reveal a role of intestine ATP7B in copper-related metabolic dysregulation (Part 3)
Not available
ORGANISM(S): Mus musculus 
ST002425 | MetabolomicsWorkbench
MetabolomicsIntegrated gut microbiome and lipidomic analyses in animal models of Wilson disease reveal a role of intestine ATP7B in copper-related metabolic dysregulation (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST002424 | MetabolomicsWorkbench
GenomicsEffect of ATP7A knockdown on gene expression in glioma stem cells
Effect of ATP7A knockdown on gene expression in glioma stem cells
PRJNA1168173 | ENA
ProteomicsProteomic analysis of HoxB8-derived macrophages in which the Slc31a1 or Atp7a genes were inactivated using CRISPR/Cas9
This project is part of a study aimed at elucidating how Mycobacterium tuberculosis responds to physiologically relevant copper levels during macrophage infection. Here, we conducted a proteomic analysis of macrophages derived from immortalized HoxB8 hematopoietic precursors, in which the Slc31a1 (e...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-25 | PXD076718 | Pride
Copper receptors Atp7a Slc31a1 Macrophages 
TranscriptomicsAmmonium tetrathiomolybdate treatment targets the copper transporter ATP7A in cisplatin-resistant breast cancer TM and cisplatin sensitize resistant breast cancer.
Chemotherapy resistance presents a major hurdle for cancer treatment. We proposed to identify the molecular changes through which breast cancer cells evolve resistance to conventional treatment, here cisplatin, so targeted therapy can be developed. Candidate approach RNAi screening was combined with...
ORGANISM(S): Homo sapiens 
2017-06-19 | GSE77515 | GEO
TranscriptomicsEffect of ATP7A knockdown on gene expression in glioma stem cells
Copper-related cell death, cuproptosis, involves accumulation of intracellular copper that triggers mitochondrial lipoylated protein aggregation and destabilization of iron–sulfur cluster proteins. Here, glioblastoma (GBM) stem cells (GSCs) displayed resistance to cuproptosis with circadian variatio...
ORGANISM(S): Homo sapiens 
2025-10-14 | GSE278671 | GEO
ProteomicsProteome labeled by a cuprous ion-responsive protein labeling reagent in the ATP7A WT and ATP7A KO living cells
We have developed a new molecular probe called CuR. This probe is selectively activated by labile Cu(I), hence enabling labeling of the proteins in Cu(I)-rich cellular environments. We applied CuR to ATP7A-WT and ATP7A-KO cells that were pretreated with or without Cu(gtsm). Next, we enriched the lab...
ORGANISM(S): Homo Sapiens (human) 
2025-01-05 | PXD048267 | JPOST Repository
UnknownExon duplications in the ATP7A gene: frequency and transcriptional behaviour.
Not available
S-EPMC3240829 | biostudies-literature
UnknownA Role for The ATP7A Copper Transporter in Tumorigenesis and Cisplatin Resistance.
Not available
S-EPMC5559955 | biostudies-literature
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