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H3K9ac ChIP-seq profiling of wild-type and Slc31a1 conditional knockout mouse bone marrow stromal cells
Age-associated bone loss is largely driven by impaired osteoblast generation from bone marrow stromal cells (BMSCs), but the metabolic and epigenetic mechanisms that regulate osteogenic commitment remain incompletely understood. This study identifies SLC31A1-mediated copper uptake as a cell-intrinsi...
ORGANISM(S): Mus musculus 
2026-07-31 | GSE337269 | GEO
Effect of Slc31a1 deletion on gene expression of Lin-Sca1+c-Kit cell in the bone marrow of mice
Chromatin accessibility profiling of wild-type and Slc31a1 conditional knockout mouse bone marrow stromal cells by ATAC-seq
This project is part of a study aimed at elucidating how Mycobacterium tuberculosis responds to physiologically relevant copper levels during macrophage infection. Here, we conducted a proteomic analysis of macrophages derived from immortalized HoxB8 hematopoietic precursors, in which the Slc31a1 (e...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-25 | PXD076718 | Pride
Copper homeostasis has been linked to human health and hematopoiesis. However, the underlying mechanisms remain elusive. Here, we demonstrate the pivotal role of the transporter Slc31a1(Ctr1) in copper uptake, during postnatal hematopoiesis. Specifically, Slc31a1-mediated copper transport sustains t...
ORGANISM(S): Mus musculus 
2025-12-31 | GSE275365 | GEO
Age-associated bone loss is largely driven by impaired osteoblast generation from bone marrow stromal cells (BMSCs), but the metabolic and epigenetic mechanisms that constrain osteogenic commitment remain incompletely understood. This study identifies SLC31A1-mediated copper uptake as a cell-intrins...
ORGANISM(S): Mus musculus 
2026-07-31 | GSE337266 | GEO
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