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ProteomicsTotal and phosphoproteome analysis of effects of topoisomerase 1 and ATR inhibitors in small cell lung cancer nuclei
Total and phosphoproteome analysis of effects of topoisomerase 1 (SN-38) and ATR (M1774) inhibitors in small cell lung cancer. Experiments performed in nuclear extract. See MetaData for more information.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-21 | MSV000091336 | MassIVE
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
ProteomicsGemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response
The DNA-damaging agent gemcitabine (GEM) is a first-line treatment for pancreatic cancer but chemoresistance is frequently observed. Several clinical trials investigate the efficacy of GEM in combination with targeted drugs including kinase inhibitors but the experimental evidence for such rational ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-18 | MSV000094340 | MassIVE
GenomicsCopper inhibits ATR and synergizes with PARP inhibitors (RNA-seq)
Copper inhibits ATR and synergizes with PARP inhibitors (RNA-seq)
PRJNA1031244 | ENA
GenomicsATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo
ATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo
PRJNA1469593 | ENA
ProteomicsThe phosphoproteomics study of Chk1 and ATR inhibitors regulation on cells
Ataxia Telangiectasia and Rad3-related (ATR) and Checkpoint Kinase 1 (Chk1) are crucial kinases in the DNA Damage Response (DDR) pathway. While the roles of ATR and Chk1 within the DDR are well-established, their roles in mitosis are not fully understood. Here, we describe that the ATR-Chk1 pathway ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD058541 | Pride
Phosphoproteomics Cdk1 Inhibitor Chk1 
ProteomicsSubstrates of the ATR kinase - Phosphoproteomics
Identification and validation of substrates of the ATR kinase by quantitative phosphoproteomics
ORGANISM(S): Homo sapiens (Human) 
2024-01-15 | PXD041250 | Pride
Phosphoproteomics Kinase Atr 
TranscriptomicsRNA-seq of human neuroblastoma cell lines treated with the ATR inhibitor BAY 1895344
To characterize the downstream gene expression response following ATR inhibition, we performed RNA-Seq after treatment of CLB-BAR and CLB-GE neuroblastoma cells with 50 nM of the ATR inhibitor BAY 1895344 for 24h and 48h
ORGANISM(S): Homo sapiens 
2021-10-21 | E-MTAB-10603 | biostudies-arrayexpress
ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo sapiens (Human) 
2015-11-24 | PXD002135 | Pride
Atr Phosphoproteomics Phosphorytion 
TranscriptomicsATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo
The DNA damage response kinase ATR restrains CDK1 activity during S and G2 phases of the cell cycle, confining CDK1-driven processes to mitosis. ATR kinase inhibitors were originally developed to potentiate chemotherapy-induced DNA damage at stalled replication forks and to disrupt DNA damage-induce...
ORGANISM(S): Mus musculus 
2026-06-01 | GSE332992 | GEO
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