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ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080795 | MassIVE
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
ProteomicsTotal and phosphoproteome analysis of effects of topoisomerase 1 and ATR inhibitors in small cell lung cancer nuclei
Total and phosphoproteome analysis of effects of topoisomerase 1 (SN-38) and ATR (M1774) inhibitors in small cell lung cancer. Experiments performed in nuclear extract. See MetaData for more information.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-21 | MSV000091336 | MassIVE
ProteomicsHuman serine/threonine protein kinase ATR LC-MS/MS
ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR actively engage in antiapoptotic role at mitochondria following DNA damage. The different functions of ATR in the nucleus and cytoplasm are ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031385 | Pride
Biotin modification Cis/trans prolyl isomerization Mass protein footprinting Bh3-like domain Atr 
ProteomicsConvergence of SIRT1 and ATR signaling to modulate replication origin dormancy
SIRT1 chromatin interactome analysis was performed to identify SIRT1 molecular targets involved in replication initiation from cells containing either WT or H363Y SIRT1. Co-IP-MS of pT530 SIRT1 from chromatin extracts was performed. Files are: 1422 WT SIRT1 untreated U2OS; 1423 WT SIRT1 H2O2 treated...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088103 | MassIVE
TranscriptomicsTranscription profiling of shoot apices from Arabidopsis wild type, teb, atr, and teb atr mutant plants
Global gene expression patterns were compared among wild-type Col-0, teb, atr, teb atr of A. thaliana using shoot apices.
ORGANISM(S): Arabidopsis thaliana 
2008-04-01 | E-MEXP-1329 | biostudies-arrayexpress
ProteomicsSubstrates of the ATR kinase - Phosphoproteomics
Identification and validation of substrates of the ATR kinase by quantitative phosphoproteomics
ORGANISM(S): Homo sapiens (Human) 
2024-01-15 | PXD041250 | Pride
Phosphoproteomics Kinase Atr 
GenomicsATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major.
ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major.
PRJEB83661 | ENA
TranscriptomicsDNA damage responses and Mec1p
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3358 | biostudies-arrayexpress
GenomicsATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo
ATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo
PRJNA1469593 | ENA
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