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TranscriptomicsTranscription profiling of human AML cell line OCI/AML2 treated with valproic acis and all trans retinoic acid
Purpose: Treatment of acute promyelocytic leukemia (APL) with the retinoid, all trans retinoic acid (ATRA), along with standard chemotherapy has significantly improved survival compared to chemotherapy alone1. ATRA mediates its benefit in APL by overcoming the transcriptional block mediated by PML-R...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2668 | biostudies-arrayexpress
ProteomicsPre and post ATRA/VP treatment proteomic and phophoproteomic profiling of AML responders and non-responders
Proteome and phosphoproteome raw files from AML patient samples obtained before and after 3 and 8 days of ATRA/valproic acid treatment
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024197 | Pride
Atra valproic acid aml 
ProteomicsResponder and non-responder proteomic and phosphoproteomic profiles to ATRA/Valproic acid before treatment
Proteomic and phosphoproteomic raw files from responder and non-responder acute myeloid leukemia patient samples before initiation of ATRA/valproic acid treatment
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024110 | Pride
Atra aml mass spectrometry valcproic acid proteomics phosphoproteomics 
GenomicsDisease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia
Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia
PRJNA415597 | ENA
TranscriptomicsDisease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive malignancy that can only be cured by intensive therapy. However, many elderly and unfit patients cannot receive such treatment due to an unacceptable risk of treatment-related morbidity and mortality. Disease-stabilizing therapy is then the only possible...
ORGANISM(S): Homo sapiens 
2017-10-25 | GSE106096 | GEO
UnknownAll-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism.
Not available
S-EPMC8907478 | biostudies-literature
TranscriptomicsOCI/AML2 ATRA AND VPA GENE EXPRESSION
Purpose: Treatment of acute promyelocytic leukemia (APL) with the retinoid, all trans retinoic acid (ATRA), along with standard chemotherapy has significantly improved survival compared to chemotherapy alone1. ATRA mediates its benefit in APL by overcoming the transcriptional block mediated by PML-R...
ORGANISM(S): Homo sapiens 
2005-05-17 | GSE2668 | GEO
UnknownTherapeutic Use of Valproic Acid and All-Trans Retinoic Acid in Acute Myeloid Leukemia-Literature Review and Discussion of Possible Use in Relapse after Allogeneic Stem Cell Transplantation.
Not available
S-EPMC8147490 | biostudies-literature
UnknownSystemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy.
Not available
S-EPMC6829623 | biostudies-literature
UnknownDisease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cells.
Not available
S-EPMC5586053 | biostudies-literature
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