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scRNA-seq of mouse immune compartment from tumours treated with ATRi ceralasertib (AZD6738)
Background: Muscle-invasive bladder cancer treatment depends on histological and molecular subtypes. While urothelial carcinoma (UC) benefits from diverse therapies, options beyond radical cystectomy for rare subtypes such as squamous cell carcinoma (SCC) remain limited. We previously demonstrated t...
ORGANISM(S): Homo sapiens 
2026-01-28 | GSE301614 | GEO
Brunello genome-wide CRISPR screen data in WT and CDK8-knockout HAP1-Cas9 treated with ATRi (AZD6738) or DMSO
Over one million cases of gastric cancer are diagnosed each year and metastatic disease continues to have a poor prognosis. A significant proportion of gastric tumors have defects in the DNA damage response pathway creating therapeutic opportunities through synthetic lethal approaches. In particular...
ORGANISM(S): Homo sapiens (Human) 
2022-11-06 | PXD034887 | Pride
KRAS mutations frequently co-occur with alterations in STK11/LKB1 and/or KEAP1, defining an aggressive subset of tumors associated with resistance to immuno- and chemotherapy. While LKB1 loss is associated with vulnerability to DNA-damage response (DDR)-based therapies, the impact of KEAP1 alteratio...
ORGANISM(S): Mus musculus 
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