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TranscriptomicsUPF2 establishes testis-specific transcriptome enriched in transcripts with shorter 3’UTRs
This report not only adds a novel mechanism to the current dogma on achieving global shortening of 3'UTRs, but also unveils a novel function of the NMD pathway in establishing tissue-specific transcriptome identity We first generated prospermatogonia-specific Upf2 conditional knockout mice (Ddx4-Cre...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-55180 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fetal livers of UPF2 null mice
Deletion of the NMD component UPF2 in fetal liver. Upf2flox/+ females were mated to Upf2flox/+; Alfp-Cre males. Fetal livers were isolated from Upf2+/+; Alfp-Cre (WT) and Upf2flox/flox; AlfpCre (UPF2 null) E16.5 and E18.5 embryos.
ORGANISM(S): Mus musculus 
2010-06-17 | E-MEXP-2248 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Deletion of the NMD component UPF2 in adult liver and response to partial hepatechtomy. Lethally irradiated Upf2flox/flox and Upf2flox/flox; Mx1Cre animals were transplanted with WT BM at 10-12 weeks of age. 5-6 following transplantion the bone marrow transplanted (BMT) animals were injected 3 times...
ORGANISM(S): Mus musculus 
2010-06-17 | E-MEXP-2249 | biostudies-arrayexpress
ProteomicsResistance to ATR Inhibitors Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2
Over one million cases of gastric cancer are diagnosed each year and metastatic disease continues to have a poor prognosis. A significant proportion of gastric tumors have defects in the DNA damage response pathway creating therapeutic opportunities through synthetic lethal approaches. In particular...
ORGANISM(S): Homo sapiens (Human) 
2022-11-06 | PXD034887 | Pride
Upf2 Gastric cancer Ab Ph Nmd 
TranscriptomicsRNAi knock down of known nonsense-mediated mRNA decay (NMD) factors in Drosophila cells
All eukaryotes studied to date have the capacity to detect and degrade mRNAs harboring premature translation termination codons (PTCs) in a process called nonsense-mediated mRNA decay (NMD) (reviewed in Wagner E & Lykke-Andersen J, 2002). This surveillance system allows the cell to prevent the expre...
ORGANISM(S): Drosophila melanogaster 
2005-11-01 | E-MEXP-202 | biostudies-arrayexpress
TranscriptomicsUpf2 in NMD pathway
Purpose: Probe the transcriptome-wide changes in the expression pattern between WT and Sertoli-specific Upf2 KO testes Methods: Total RNA were extracted from WT and Sertoli-specific Upf2 KO testes in triplicates and subject to deep-sequencing in Ion Torrent seq platform. Results: Using an optimized ...
ORGANISM(S): Mus musculus 
2014-09-06 | E-GEOD-58405 | biostudies-arrayexpress
GenomicsIdentification of Upf2 and Upf3 targets in N. castellii using RNA-Seq
Identification of Upf2 and Upf3 targets in N. castellii using RNA-Seq
PRJNA1311609 | ENA
GenomicsRNA sequencing of blastocyst-stage mouse embryos in the presence or absence of RNA decay activator UPF2
RNA sequencing of blastocyst-stage mouse embryos in the presence or absence of RNA decay activator UPF2
PRJNA789489 | ENA
TranscriptomicsMicroarray profiling of UPF2-deficient mouse GV oocytes.
To study the role of UPF2 during oogenesis, Upf2 was conditionally deleted in growing oocytes. Total RNA samples from UPF2-deficient GV oocytes were subjected to array profiling. The control samples for this experiment can be found in E-MTAB-5056.
ORGANISM(S): Mus musculus 
2019-01-14 | E-MTAB-7064 | biostudies-arrayexpress
UnknownImpact of UPF2 on the levels of CD81 on extracellular vesicles.
Not available
S-EPMC11625909 | biostudies-literature
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