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GenomicsGlobal genomic profiling of p53-regulated genes
p53 is a critical tumor suppressor and works as a stress-induced transcription factor to induce target genes mediating apoptosis, cell cycle arrest and senescence or other responses. To gain new insights into p53 biology, we used high-throughput sequencing to analyze global p53 transcriptional netwo...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46240 | biostudies-arrayexpress
UnknownEpigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state.
Not available
S-EPMC10810848 | biostudies-literature
GenomicsIntegrative Genomic Analysis Reveals Widespread Enhancer Regulation by p53 in Response to DNA Damage
The tumor suppressor p53 has been studied extensively as a direct transcriptional activator of protein-coding genes. Recent studies, however, have shed light on novel regulatory functions of p53 within noncoding regions of the genome. Here, we use a systematic approach that integrates transcriptom...
ORGANISM(S): Homo sapiens 
2015-04-18 | E-GEOD-55727 | biostudies-arrayexpress
UnknownEssential role for centromeric factors following p53 loss and oncogenic transformation.
Not available
S-EPMC5393061 | biostudies-literature
TranscriptomicsA large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response
Recently, more than a thousand large intergenic non-coding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of ...
ORGANISM(S): Mus musculus 
2010-08-09 | E-GEOD-21761 | biostudies-arrayexpress
TranscriptomicsRibosomal protein S6 Rps6 heterozygous null deletion effect on footpad epidermis
Mutant and non-mutant footpad. McGowan et al. in press Keywords: Mutant vs. non-mutant The tissue (footpad epidermis) is from a conditional heterozygous null deletion of Rps6. One copy of Rps6 was deleted from keratinocytes in the skin using the K5.Cre transgene. K5Cre x Rps6^loxP
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-11331 | biostudies-arrayexpress
UnknownA p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.
Not available
S-EPMC8319123 | biostudies-literature
ProteomicsModeling cooperative tumor suppression in the p53 target gene network with in vivo genetic screens and multi-omics
The tumor suppressor TP53 is the most frequently mutated gene in human cancer. TP53 encodes a transcriptional activator that induces numerous downstream target genes, but those genes critical for tumor suppression remain elusive. To shed light on the downstream target genes important for tumor suppr...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-17 | PXD047240 | Pride
Mouse Embryonic fibroblast P53 
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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