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ProteomicsPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation; however, the origin, abundance, and functional relevance of these modifications are largely unclear. Nonetheless, mitochondria possess multiple resident phosphatases, suggesting that protein dephosphorylation may be broadly important for mitoc...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-29 | PXD012743 | Pride
Mitochondia Pptc7 Phosphoproteome 
TranscriptomicsTranscription profiling and QTL mapping of 60 mice from an F2 sample segregating for diabetes to generate expression trait correlations and expression quantitative trait locus mapping.
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts. To map gene regulatory pathways, we used microarray-derived gene expression measurements in 60 individuals of an F2 sample segregat...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3330 | biostudies-arrayexpress
TranscriptomicsGlobal Identification of Protein PTMs in a Single-pass Database Search
Bottom-up proteomics database search algorithms used for peptide identification cannot comprehensively identify posttranslational modifications (PTMs) in a single-pass because of high false discovery rates (FDRs). A new approach to database searching enables Global PTM (G-PTM) identification by excl...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-59956 | biostudies-arrayexpress
TranscriptomicsRNA-seq alignment to individualized genomes
The source of most errors in RNA sequencing (RNA-seq) read alignment is in the repetitive structure of the genome and not with the alignment algorithm. Genetic variation away from the reference sequence exacerbates this problem causing reads to be assigned to the wrong location. We developed a metho...
ORGANISM(S): Mus musculus 
2014-06-10 | E-GEOD-45684 | biostudies-arrayexpress
ProteomicsSample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for targeting entire pathways of proteins selected from ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-08-11 | MSV000090110 | MassIVE
ProteomicsTarget deconvolution of SW016789 in human and mouse Beta cells
The target of SW016789 is unknown (PMCID: PMC9225822). This compound was identified in a high-throughput screen for insulin secretion modulators and was subsequently discovered to cause hypersecretory stress in beta cells. A photoaffinity probe was designed, Z629, based upon the structure of SW01678...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-03-13 | MSV000094310 | MassIVE
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