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Polyadenylation of mRNA precursors is mediated by a large multisubunit protein complex. Here we show that RBBP6 (retinoblastoma-binding protein 6), identified initially as an Rb- and p53-binding protein, is a component of this complex and functions in 3' processing in vitro and in vivo. RBBP6 associ...
ORGANISM(S): Homo sapiens 
In the context of anti-tumor immunity, activated T cells secrete interferon-gamma (IFNγ) to induce indoleamine 2,3-dioxygenase (IDO1) in the target cancer cells. High IDO1 levels deplete tryptophan, leading to aberrant protein production due to tryptophan to phenylalanine codon reassignments (W>F su...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD060710 | Pride
Whole-genome expression microarray experiments were conducted to assess the response of C. metallidurans CH34 to aqueous Au(III)-chloride and identify possible biochemical pathways for Au detoxification. Four microarray experiments were conducted to assess gold response at low, medium and high Au(II...
ORGANISM(S): Ralstonia metallidurans CH34 
Although immediate early genes (IEGs) such as Bdnf, Arc and Egr1, have been implicated in plasticity, the larger pathways related to memory and memory disorders are not well understood. Here, we combined statistical Affymetrix microarray and behavioral analyses to identify key genes and pathways ass...
ORGANISM(S): Rattus norvegicus 
We used Au nanoparticles (Au-NPs) as a model for studying particle specific effects of manufactured nanomaterials (MNMs) by examining the toxicogenomic responses in a model soil organism, free living nematode Caenorhabditis elegans. Global genome expression for nematodes exposed to 4-nm citrate-coat...
ORGANISM(S): Caenorhabditis elegans 
The yeast M-NM-6-crystallin Zta1p interacts specifically with RNA sequences rich in adenine and uracil (AU-rich element). We have looked for possible targets of Zta1p through a comparative transcriptional analysis of the yeast defective in ZTA1 (M-NM-^Tzta1) versus the wild-type by microarray. This ...
ORGANISM(S): Saccharomyces cerevisiae 
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